Home LiteratureArticle Details
PMID: 835573 Published · ppublish English Comparative Study Journal Article

Comparison of GdA and GdB activities in Nigerians. A study of the variation of the G6PD activity.

American journal of human genetics ·Vol. 29 ·No. 1 ·1977-01-00 ·Pages 31-6

Battistuzzi G, Esan GJ, Fasuan FA, Modiano G, Luzzatto L

Abstract

We report a comparison between G6PD enzyme activities in lysates from GdA and GdB Nigerian healthy males. We confirm the previously reported higher mean activity of G6PD B. An analysis of the enzyme activity variation has been performed: the relative amount of variation found to be associated with this polymorphism is about 8%. A comparison has been made with other genetic polymorphisms.

MeSH Terms
Child Electrophoresis Erythrocytes/enzymology Glucosephosphate Dehydrogenase/blood Hemoglobins Humans Male Nigeria Phenotype Polymorphism, Genetic
Chemicals
Hemoglobins Glucosephosphate Dehydrogenase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Battistuzzi G
Esan G J
Fasuan F A
Modiano G
Luzzatto L
References (18)
18 references, click to expand
  1. New developments in glucose-6-phosphate dehydrogenase deficiency.
    Isr J Med Sci. 1973 Sep-Oct;9(9):1484-98 PMID: 4152522
  2. A single amino Acid substitution (asparagine to aspartic Acid) between normal (b+) and the common negro variant (a+) of human glucose-6-phosphate dehydrogenase.
    Proc Natl Acad Sci U S A. 1967 Mar;57(3):835-40 PMID: 16591538
  3. Enzyme polymorphisms in man.
    Proc R Soc Lond B Biol Sci. 1966 Mar 22;164(995):298-310 PMID: 4379519
  4. Comparative activity of red cell adenosine deaminase allelic forms.
    Nature. 1974 Oct 25;251(5477):711-3 PMID: 4427666
  5. Genetic variants of glucose 6-phosphate dehydrogenase from human erythrocytes: unique properties of the A - variant isolated from "deficient" cells.
    Proc Natl Acad Sci U S A. 1972 Apr;69(4):946-50 PMID: 4502945
  6. Genetic factors in malaria.
    Bull World Health Organ. 1974;50(3-4):195-202 PMID: 4613502
  7. Characterization of glucose-6-phosphate dehydrogenase in Thailand. The occurrence of 6 variants among 50 G-6-PD deficient Thai.
    Humangenetik. 1973 Mar 23;18(1):39-46 PMID: 4721339
  8. Variants of glucose-6-phosphate dehydrogenase.
    Ann N Y Acad Sci. 1971 Jul 6;179:636-43 PMID: 4936780
  9. Haemoglobin and glucose-6-phosphate dehydrogenase variants: distribution in relation to malaria endemicity in a Togolese population.
    Z Tropenmed Parasitol. 1972 Mar;23(1):56-62 PMID: 5050532
  10. Population genetics of haemoglobin variants, thalassaemia and glucose-6-phosphate dehydrogenase deficiency, with particular reference to the malaria hypothesis.
    Bull World Health Organ. 1966;34(3):379-93 PMID: 5296398
  11. Electrophoretic diversity of glucose-6-phosphate dehydrogenase among Greeks.
    Am J Hum Genet. 1970 Sep;22(5):587-96 PMID: 5516240
  12. Genetic variants of human erythrocyte glucose 6-phosphate dehydrogenase. I. Regulation of activity by oxidized and reduced nicotinamide-adenine dinucleotide phosphate.
    Biochemistry. 1971 Feb 2;10(3):415-9 PMID: 5543967
  13. Genetic variants of human erythrocyte glucose 6-phosphate dehydrogenase. II. In vitro and in vivo function of the A- variant.
    Biochemistry. 1971 Feb 2;10(3):420-3 PMID: 5543968
  14. Enzymic properties of different types of human erythrocyte glucose-6-phosphate dehydrogenase, with characterization of two new genetic variants.
    J Clin Invest. 1968 Aug;47(8):1833-42 PMID: 5666113
  15. Relationship between the genes for glucose-6-phosphate dehydrogenase and for haemoglobin in a Nigerian population.
    Nature. 1968 Sep 7;219(5158):1041-2 PMID: 5673357
  16. GENETIC VARIATIONS IN THE QUANTITATIVE CONTROL OF ERYTHROCYTE GLUCOSE-6-PHOSPHATE DEHYDROGENASE ACTIVITY.
    Ann Hum Genet. 1964 Sep;28:61-70 PMID: 14204852
  17. Standardization of hemoglobinometry. II. The hemiglobincyanide method.
    Clin Chim Acta. 1961 Jul;6:538-44 PMID: 14453500
  18. Studies of polymorphic traits for the characterization of populations. African populations south of the Sahara.
    Isr J Med Sci. 1973 Sep-Oct;9(9):1181-94 PMID: 4359638
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1977-01-00
Pages
31-6
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685233
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com