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PMID: 8349118 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Empirical tests of some predictions from coalescent theory with applications to intraspecific phylogeny reconstruction.

Genetics ·Vol. 134 ·No. 3 ·1993-07-00 ·Pages 959-69

Crandall KA, Templeton AR

Abstract

Empirical data sets of intraspecific restriction site polymorphism in Drosophila have been gathered in order to test hypotheses derived from coalescent theory. Three main ideas are tested: (1) haplotype frequency in the sample contains information on the topological position of a given haplotype in a cladogram, (2) the frequency of a haplotype is related to the number of mutational connections to other haplotypes in the cladogram and (3) geographic location can be used to infer topological positioning of haplotypes in a cladogram. These relationships can then be used to better estimate intraspecific phylogenies in two ways: (1) rooting the phylogeny and (2) resolving ambiguities in a cladogram. This information will allow one to reduce the number of alternative phylogenies and incorporate the uncertainties involved in reconstructing intraspecific phylogenies into subsequent analyses that depend heavily on the topology of the tree.

MeSH Terms
Animals Drosophila/classification,genetics Drosophila melanogaster/classification,genetics Haplotypes Models, Genetic Phylogeny Polymorphism, Genetic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Crandall K A
Department of Biology, Washington University, St. Louis, Missouri 63130-4899.
Templeton A R
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/134.3.959
Published
1993-07-00
Pages
959-69
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1205530
Subset
IM
Grants
NHLBI NIH HHS · 1 R01 HL39107 · United States
NIGMS NIH HHS · R01 GM31571 · United States
External Links
PubMed source DOI: 10.1093/genetics/134.3.959 PMC Full Text View journal details
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