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PMID: 6291056 Published · ppublish English Journal Article

Restriction map variation in the Adh region of Drosophila.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 18 ·1982-09-00 ·Pages 5631-5

Langley CH, Montgomery E, Quattlebaum WF

Abstract

Restriction maps of a 12,000-nucleotide region containing the alcohol dehydrogenase (Adh) locus of the second chromosome of Drosophila were determined for (i) 18 independent second chromosome stocks of D. melanogaster established from several natural populations and (ii) five closely related Drosophila species. All of the detected map differences appear to lie outside the Adh coding block. Four polymorphic restriction sites and four insertion/deletion variants were identified among D. melanogaster chromosomes. The estimated heterozygosity per nucleotide site was 0.006. The relative distributions of restriction sites and insertion/deletion variations among subpopulations and species suggest that the insertion/deletion variation may be mildly deleterious.

MeSH Terms
Alcohol Dehydrogenase Alcohol Oxidoreductases/genetics Animals DNA Restriction Enzymes Drosophila melanogaster/enzymology,genetics Genes Genetic Variation Isoenzymes/genetics Nucleic Acid Hybridization
Chemicals
Isoenzymes Alcohol Oxidoreductases Alcohol Dehydrogenase DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Langley C H
Montgomery E
Quattlebaum W F
References (33)
33 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.18.5631
Published
1982-09-00
Pages
5631-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC346958
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.79.18.5631 PMC Full Text View journal details
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