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PMID: 8327469 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Thalidomide inhibits the replication of human immunodeficiency virus type 1.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 90 ·No. 13 ·1993-07-01 ·Pages 5974-8

Makonkawkeyoon S, Limson-Pobre RN, Moreira AL, Schauf V, Kaplan G

Abstract

Thalidomide, a selective inhibitor of tumor necrosis factor alpha (TNF-alpha) synthesis, suppresses the activation of latent human immunodeficiency virus type 1 (HIV-1) in a monocytoid (U1) line. The inhibition is dose dependent and occurs after exposure of the cells to recombinant TNF-alpha, phorbol myristate acetate, lipopolysaccharide, and other cytokine combinations. Associated with HIV-1 inhibition is a reduction in agonist-induced TNF-alpha protein and mRNA production. Thalidomide inhibition of virus replication in the phorbol myristate acetate- and recombinant TNF-alpha-stimulated T-cell line ACH-2 is not observed. The presence of thalidomide also inhibits the activation of virus in the peripheral blood mononuclear cells of 16 out of 17 patients with advanced HIV-1 infection and AIDS. These results suggest the use of thalidomide in a clinical setting to inhibit both virus replication and the TNF-alpha-induced systemic toxicity of HIV-1 and opportunistic infections.

MeSH Terms
Acquired Immunodeficiency Syndrome/drug therapy,microbiology Adult Cell Line Female HIV Infections/drug therapy HIV-1/drug effects,physiology Humans Leukocytes, Mononuclear/drug effects,microbiology Male Middle Aged Monocytes/drug effects,microbiology RNA, Messenger/genetics,metabolism T-Lymphocytes/drug effects,microbiology Thalidomide/pharmacology,therapeutic use Tumor Necrosis Factor-alpha/biosynthesis,genetics Virus Activation/drug effects Virus Replication/drug effects
Chemicals
RNA, Messenger Tumor Necrosis Factor-alpha Thalidomide
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Makonkawkeyoon S
Rockefeller University, New York, NY 10021.
Limson-Pobre R N
Moreira A L
Schauf V
Kaplan G
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.90.13.5974
Published
1993-07-01
Pages
5974-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC46849
Subset
IM
Grants
NIAID NIH HHS · AI-22616 · United States
NIAID NIH HHS · AI-24775 · United States
External Links
PubMed source DOI: 10.1073/pnas.90.13.5974 PMC Full Text View journal details
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