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PMID: 8285636 Published · ppublish English Journal Article

Bactericidal activity of the fluoroquinolone WIN 57273 against high-level gentamicin-resistant Enterococcus faecalis.

Antimicrobial agents and chemotherapy ·Vol. 37 ·No. 11 ·1993-11-00 ·Pages 2470-3

Noskin GA, Mehl P, Warren JR

Abstract

The fluoroquinolone WIN 57273 showed identical bactericidal activities (MBC for 90% of the strains = 0.25 micrograms/ml) for bacteremic strains of Enterococcus faecalis with and without high-level gentamicin resistance. WIN 57273 was bactericidal in time-kill measurements with highly gentamicin-resistant, ciprofloxacin-susceptible strains of E. faecalis. However, WIN 57273 was indifferent with penicillin for gentamicin-resistant E. faecalis and was not bactericidal for ciprofloxacin-resistant E. faecalis.

MeSH Terms
Anti-Infective Agents/pharmacology Drug Resistance, Microbial Enterococcus faecalis/drug effects Fluoroquinolones Gentamicins/pharmacology Quinolones/pharmacology Time Factors
Chemicals
Anti-Infective Agents Fluoroquinolones Gentamicins Quinolones Win 57273
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Noskin G A
Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611.
Mehl P
Warren J R
References (15)
15 references, click to expand
  1. Endocarditis due to streptomycin-susceptible Enterococcus faecalis with high-level gentamicin resistance.
    Arch Intern Med. 1989 Aug;149(8):1873-5 PMID: 2504123
  2. High-content aminoglycoside disks for determining aminoglycoside-penicillin synergy against Enterococcus faecalis.
    J Clin Microbiol. 1988 Feb;26(2):257-60 PMID: 3125218
  3. In vitro evaluation of WIN 57273, a new broad-spectrum fluoroquinolone.
    Antimicrob Agents Chemother. 1990 Feb;34(2):306-13 PMID: 2327779
  4. In vitro and in vivo activities of a new quinolone, WIN 57273, possessing potent activity against gram-positive bacteria.
    Antimicrob Agents Chemother. 1990 Apr;34(4):568-75 PMID: 2344163
  5. WIN 57273, a new fluoroquinolone with enhanced in vitro activity versus gram-positive pathogens.
    Antimicrob Agents Chemother. 1990 Jul;34(7):1376-80 PMID: 2117417
  6. Multicenter evaluation of the in vitro activities of three new quinolones, sparfloxacin, CI-960, and PD 131,628, compared with the activity of ciprofloxacin against 5,252 clinical bacterial isolates.
    Antimicrob Agents Chemother. 1991 Apr;35(4):764-6 PMID: 2069384
  7. High-level gentamicin resistance in Enterococcus faecalis bacteremia.
    J Infect Dis. 1991 Dec;164(6):1212-5 PMID: 1955722
  8. Antimicrobial activity of DU-6859, a new potent fluoroquinolone, against clinical isolates.
    Antimicrob Agents Chemother. 1992 Jul;36(7):1491-8 PMID: 1324647
  9. Comparative in vitro activity of PD 127391, a new fluoroquinolone agent, against susceptible and resistant clinical isolates of gram-positive cocci.
    Antimicrob Agents Chemother. 1992 Jun;36(6):1325-8 PMID: 1329621
  10. Comparative in vitro activities of a new quinolone, OPC-17116, possessing potent activity against gram-positive bacteria.
    Antimicrob Agents Chemother. 1992 Oct;36(10):2185-91 PMID: 1332589
  11. Increasing resistance of enterococci to ciprofloxacin.
    Antimicrob Agents Chemother. 1992 Nov;36(11):2533-5 PMID: 1489199
  12. In vitro activity of CP-99,219, a new fluoroquinolone, against clinical isolates of gram-positive bacteria.
    Antimicrob Agents Chemother. 1993 Feb;37(2):366-70 PMID: 8452372
  13. In vitro activity of ciprofloxacin combined with azlocillin.
    Antimicrob Agents Chemother. 1985 Dec;28(6):849-50 PMID: 2935078
  14. In vitro and in vivo activity of ciprofloxacin against enterococci isolated from patients with infective endocarditis.
    Antimicrob Agents Chemother. 1987 Mar;31(3):430-3 PMID: 3579260
  15. Synergy of fluoroquinolones with other antimicrobial agents.
    Rev Infect Dis. 1989 Jul-Aug;11 Suppl 5:S1025-35 PMID: 2505355
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.37.11.2470
Published
1993-11-00
Pages
2470-3
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC192411
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.37.11.2470 PMC Full Text View journal details
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