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PMID: 1489199 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Increasing resistance of enterococci to ciprofloxacin.

Antimicrobial agents and chemotherapy ·Vol. 36 ·No. 11 ·1992-11-00 ·Pages 2533-5

Schaberg DR, Dillon WI, Terpenning MS, Robinson KA, Bradley SF, Kauffman CA

Abstract

We determined that resistance to ciprofloxacin has emerged in enterococci over the last 5 years in our hospital, mainly in strains demonstrating the phenotype of high-level gentamicin resistance. All high-level-gentamicin-resistant isolates from 1985 and 1986 were susceptible, whereas 24% of isolates from 1989 and 1990 were resistant to ciprofloxacin. Plasmid and genomic DNA typing showed at least six unique strains exhibiting resistance, but one type accounted for 80% of recent resistant isolates, suggesting a role for cross infection in the emergence of resistance.

MeSH Terms
Ciprofloxacin/pharmacology DNA, Bacterial/analysis,genetics Drug Resistance, Microbial/physiology Enterococcus/drug effects,genetics Gentamicins/pharmacology Humans Microbial Sensitivity Tests Time Factors
Chemicals
DNA, Bacterial Gentamicins Ciprofloxacin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Schaberg D R
Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor 48109.
Dillon W I
Terpenning M S
Robinson K A
Bradley S F
Kauffman C A
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.36.11.2533
Published
1992-11-00
Pages
2533-5
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC284368
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.36.11.2533 PMC Full Text View journal details
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