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PMID: 8278388 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Physical association between nonhomologous chromosomes precedes distributive disjunction in yeast.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 1 ·1994-01-04 ·Pages 331-4

Loidl J, Scherthan H, Kaback DB

Abstract

During meiosis homologous chromosomes normally pair, undergo reciprocal recombination, and then segregate from each other. Distributive disjunction is the meiotic segregation that is observed in the absence of homologous recombination and can occur for both nonrecombinant homologous chromosomes and completely nonhomologous chromosomes. While the mechanism of distributive disjunction is not known, several models have been presented that either involve or are completely independent of interactions between the segregating chromosomes. In this report, we demonstrate that distributive disjunction in Saccharomyces cerevisiae is preceded by an interaction between nonhomologous chromosomes.

MeSH Terms
Chromosomes, Fungal/physiology In Situ Hybridization, Fluorescence Meiosis Monosomy Recombination, Genetic Saccharomyces cerevisiae/genetics Synaptonemal Complex
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Loidl J
Department of Cytology and Genetics, University of Vienna, Austria.
Scherthan H
Kaback D B
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.1.331
Published
1994-01-04
Pages
331-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC42941
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.91.1.331 PMC Full Text View journal details
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