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PMID: 827327 Published · ppublish English Journal Article

Prevalence of multiple antibiotic resistance in Neisseria gonorrhoeae.

The British journal of venereal diseases ·Vol. 52 ·No. 6 ·1976-12-00 ·Pages 384-6

Platt DJ

Abstract

The susceptibility of 100 strains of Neisseria gonorrhoeae to five antimicrobial agents (penicillin, streptomycin, oxytetracycline, sulphamethoxazole, and gentamicin) was examined. Three strains were resistant to each antimicrobial, fourteen exhibited resistance to three or four of the five compounds tested, and 49 were resistant to a single agent, or to pairs of the selected agents. 34 strains were found to be fully sensitive to all of the compounds tested. It is suggested that resistance to gentamicin and sulphamethoxazole may be determined by a multiple resistance gene. The overall frequency of penicillin resistance was found to be 26-5 per cent (MIC greater than 0-06 mug/ml.), suggesting a significant decrease in resistance since 1968.

MeSH Terms
Anti-Bacterial Agents/pharmacology Gentamicins/pharmacology Neisseria gonorrhoeae/drug effects Oxytetracycline/pharmacology Penicillin Resistance Penicillins/pharmacology Streptomycin/pharmacology Sulfamethoxazole/pharmacology
Chemicals
Anti-Bacterial Agents Gentamicins Penicillins Sulfamethoxazole Oxytetracycline Streptomycin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Platt D J
References (19)
19 references, click to expand
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Article Info
Journal
The British journal of venereal diseases
Abbr.
Br J Vener Dis
ISSN
0007-134X
DOI
10.1136/sti.52.6.384
Published
1976-12-00
Pages
384-6
Language
English
Region
England
NLM ID
0421042
PMCID
PMC1045315
Subset
IM
External Links
PubMed source DOI: 10.1136/sti.52.6.384 PMC Full Text
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