Home LiteratureArticle Details
PMID: 4209067 Published · ppublish English Journal Article

Antibiotic disk susceptibility tests with Neisseria gonorrhoeae.

Antimicrobial agents and chemotherapy ·Vol. 5 ·No. 3 ·1974-03-00 ·Pages 210-6

Maier TW, Beilstein HR, Zubrzycki L

Abstract

We have used a standardized disk diffusion procedure to test the susceptibility of 892 isolates of Neisseria gonorrhoeae to six antibiotics. The disk diffusion test described is a modification of the disk test of Bauer, Kirby, Sherris, and Turck, which is widely used for susceptibility testing of fast-growing, aerobic pathogens. With all six antibiotics (penicillin, ampicillin, tetracycline, erythromycin, chloramphenicol, and cephaloridine), disk test results were found to be reproducible and correlated well with the minimal inhibitory concentration as determined by an agar dilution procedure. The coefficients of correlation ranged from -0.79 with cephaloridine to -0.93 with penicillin. The technique described for disk susceptibility testing of gonococci can be used both for research and clinical purposes.

MeSH Terms
Anti-Bacterial Agents/pharmacology Microbial Sensitivity Tests Neisseria gonorrhoeae/drug effects
Chemicals
Anti-Bacterial Agents
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Maier T W
Beilstein H R
Zubrzycki L
References (21)
21 references, click to expand
  1. Increased susceptibility of Neisseria gonorrhoea from a rural area.
    Antimicrob Agents Chemother. 1973 Apr;3(4):503-5 PMID: 4208291
  2. Single-dose antibiotic treatment of asymptomatic gonorrhea in hospitalized women.
    N Engl J Med. 1970 Jul 2;283(1):1-6 PMID: 4986777
  3. Single-dose aqueous procaine penicillin G therapy for gonorrhea: use of probenecid and cause of treatment failure.
    J Infect Dis. 1973 Apr;127(4):455-60 PMID: 4632882
  4. Relationships between the sensitivities in vitro of Neisseria gonorrhoeae to spiramycin, penicillin, streptomycin, tetracycline, and erythromycin.
    Br J Vener Dis. 1969 Sep;45(3):223-7 PMID: 4981352
  5. Comparative investigations of the sensitivity of N. gonorrhoeae to penicillin.
    Acta Pathol Microbiol Scand. 1963;57:235-55 PMID: 13981907
  6. Effects of penicillin, streptomycin, and tetracycline on N. gonorrhoeae isolated in 1944 and in 1957.
    Br J Vener Dis. 1958 Dec;34(4):227-39 PMID: 13618566
  7. Therapeutic trial of trimethoprim as a potentiator of sulphonamides in gonorrhoea.
    Br J Vener Dis. 1967 Sep;43(3):161-5 PMID: 5233504
  8. The problem of penicillin resistant gonococci.
    Br J Vener Dis. 1968 Dec;44(4):315-8 PMID: 4974338
  9. Antibiotic susceptibility testing by a standardized single disk method.
    Am J Clin Pathol. 1966 Apr;45(4):493-6 PMID: 5325707
  10. Treatment of gonorrhoea by one oral dose of ampicillin and probenecid combined.
    Br J Vener Dis. 1969 Sep;45(3):235-7 PMID: 5346421
  11. Single-dose oral treatment of gonorrhea in men and women, using ampicillin alone and combined with probenecid.
    Br J Vener Dis. 1971 Dec;47(6):443-7 PMID: 5003650
  12. Antibiotic resistance in Neisseria gonorrhoeae.
    Med Clin North Am. 1972 Sep;56(5):1133-44 PMID: 4262305
  13. Studies of venereal disease. I. Probenecid-procaine penicillin G combination and tetracycline hydrochloride in the treatment of "penicillin-resistant" gonorrhea in men.
    JAMA. 1967 Nov 6;202(6):461-73 PMID: 4963707
  14. Further studies of penicillin resistant gonococci.
    Br J Vener Dis. 1970 Oct;46(5):404-5 PMID: 4991034
  15. Single oral dose ampicillin-probenecid treatment of gnorrhea in the male.
    JAMA. 1971 Mar 1;215(9):1449-53 PMID: 5107620
  16. A survey of problems in the antibiotic treatment of gonorrhoea. With special reference to South-East Asia.
    Br J Vener Dis. 1970 Jun;46(3):217-42 PMID: 4246923
  17. Sensitivity to penicillin of Neisseria gonorrhoeae. Relationship to the results of treatment.
    Br J Vener Dis. 1969 Jun;45(2):151-3 PMID: 4977824
  18. Comparative study of gonococcal susceptibility to penicillin in the United States, 1955-1969.
    J Infect Dis. 1970 Nov;122(5):459-61 PMID: 4990947
  19. Treatment of gonorrhoea with aqueous benzyl penicillin plus probenecid.
    Acta Derm Venereol. 1971;51(4):311-4 PMID: 4105783
  20. Improved medium selective for cultivation of N. gonorrhoeae and N. meningitidis.
    Public Health Rep. 1966 Jun;81(6):559-62 PMID: 4957043
  21. Problems in diagnosis, treatment and control of gonorrheal infections. IV. The correlation between the dose of penicillin, concentration in blood, IC-50-values of gonococci and results of treatment.
    Acta Derm Venereol. 1965;45(3):242-53 PMID: 4163244
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.5.3.210
Published
1974-03-00
Pages
210-6
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC428950
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.5.3.210 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2