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PMID: 8265339 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.

Nucleic acids research ·Vol. 21 ·No. 23 ·1993-11-25 ·Pages 5289-93

Hu B, Burkhart R, Schulte D, Musahl C, Knippers R

Abstract

Monospecific antibodies against an oligopeptide, conserved among the Mcm class of yeast replication proteins, were used to screen a human cDNA library. Eight of the isolated cDNA clones have the potential to code for sections of proteins with high sequence similarities to the yeast proteins Mcm3 and Cdc46 from Saccharomyces cerevisiae and Cdc21 from S. pombe. Our results establish a novel and highly conserved family of nuclear proteins in mammalian cells.

MeSH Terms
Amino Acid Sequence Cell Cycle Proteins Cloning, Molecular Consensus Sequence DNA Replication DNA, Complementary/genetics DNA-Binding Proteins Fungal Proteins/genetics Humans Minichromosome Maintenance Complex Component 3 Minichromosome Maintenance Complex Component 4 Molecular Sequence Data Multigene Family Nuclear Proteins/genetics Oligopeptides/chemistry Schizosaccharomyces pombe Proteins Sequence Alignment Sequence Homology, Amino Acid Transcription Factors
Chemicals
Cell Cycle Proteins DNA, Complementary DNA-Binding Proteins Fungal Proteins MCM3 protein, human MCM5 protein, human Nuclear Proteins Oligopeptides Schizosaccharomyces pombe Proteins Transcription Factors Minichromosome Maintenance Complex Component 3 Minichromosome Maintenance Complex Component 4 mcm4 protein, S pombe
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hu B
Division of Biology, Universitèt Konstanz, Germany.
Burkhart R
Schulte D
Musahl C
Knippers R
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21 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/21.23.5289-a
Published
1993-11-25
Pages
5289-93
Language
English
Region
England
NLM ID
0411011
PMCID
PMC310560
Subset
IM
Databases
GENBANK
X62153, X62154, X74794, X74795, X74796
External Links
PubMed source DOI: 10.1093/nar/21.23.5289-a PMC Full Text View journal details
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