The complete intron/exon structure of Ephydatia mülleri fibrillar collagen gene suggests a mechanism for the evolution of an ancestral gene module.

Journal of molecular evolution ·Vol. 37 ·No. 3 ·1993-09-00 ·Pages 254-9

Exposito JY, van der Rest M, Garrone R

Abstract

We have completed the analysis of a genomic clone, G238, that contains most of the coding region of the sponge COLF1 fibrillar collagen gene. The main triple helical domain is encoded by 31 exons. Except for the 5' junction exon and the two last 3' exons (126 and 18 base pairs), all these exons are related to a 54-bp unit and begin with an intact glycine codon. A good correlation can be made between this sponge gene and a vertebrate fibrillar collagen gene, revealing the high conservation of the members of this family during evolution. The reconstitution of an ancestral collagen gene can be made by considering all the exon/intron junctions of these genes. We suggest that such an ancestral gene arose from multiple duplications of a 54-bp exon and a (54 + 45)-bp module.

Related Genes

COL1A2 COL2A1 COLF1 COLP1&agr

MeSH Terms

Amino Acid Sequence Animals Base Sequence Biological Evolution Collagen/chemistry,genetics Exons Genes Introns Models, Genetic Molecular Sequence Data Multigene Family Porifera/genetics Protein Structure, Secondary Sea Urchins/genetics Vertebrates/genetics

Chemicals

Collagen

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Exposito J Y

Institut de Biologie et Chimie des Protéines, CNRS UPR 412, Université Claude Bernard, Lyon, France.

van der Rest M

Garrone R

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Article Info

Journal

Journal of molecular evolution

Abbr.

J Mol Evol

ISSN

0022-2844

DOI

10.1007/BF00175502

Published

1993-09-00

Pages

254-9

Language

English

Region

Germany

NLM ID

0360051

Subset

Databases

GENBANK

X69818

External Links

PubMed source DOI: 10.1007/BF00175502 View journal details

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The complete intron/exon structure of Ephydatia mülleri fibrillar collagen gene suggests a mechanism for the evolution of an ancestral gene module.

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