The application of mitochondrial DNA typing to the study of white Caucasian genetic identification.

International journal of legal medicine ·Vol. 106 ·No. 2 ·1993-00-00 ·Pages 85-90

Piercy R, Sullivan KM, Benson N, Gill P

Abstract

Mitochondrial DNA (mtDNA) from 100 unrelated British White Caucasians was extracted, amplified and directly sequenced. Sequences of approximately 800 nucleotides were obtained from 2 hypervariable segments within the non-coding region of the mitochondrial genome. A total of 91 different sequences were observed with an average nucleotide diversity of 1.1%. The most diverse pair of sequences differed at 3.6% of their nucleotide (nt) sites. Comparison to a consensus reference sequence showed that each region was polymorphic to a similar extent. Different methods of genetic analysis were used to examine the variation in each region, including pairwise comparisons, which demonstrated that although the data did not fit a Poisson distribution, the fit was closer to a Negative Binomial distribution.

MeSH Terms

Base Sequence DNA, Mitochondrial/genetics England Genetics, Population Humans Polymerase Chain Reaction Polymorphism, Genetic Wales Whites/genetics

Chemicals

DNA, Mitochondrial

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Piercy R

Central Research and Support Establishment, Forensic Science Service, Reading, Berkshire, UK.

Sullivan K M

Benson N

Gill P

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Article Info

Journal

International journal of legal medicine

Abbr.

Int J Legal Med

ISSN

0937-9827

DOI

10.1007/BF01225046

Published

1993-00-00

Pages

85-90

Language

English

Region

Germany

NLM ID

9101456

Subset

External Links

PubMed source DOI: 10.1007/BF01225046 View journal details

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The application of mitochondrial DNA typing to the study of white Caucasian genetic identification.

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