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PMID: 8146199 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Neurotensin excites basal forebrain cholinergic neurons: ionic and signal-transduction mechanisms.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 7 ·1994-03-29 ·Pages 2853-7

Farkas RH, Nakajima S, Nakajima Y

Abstract

The whole-cell patch-clamp technique was used to investigate the effect of neurotensin on cholinergic neurons cultured from the rat nucleus basalis of Meynert. Neurotensin excited the neurons by inducing an initial inward current carried, at least in part, by Na+ and by reducing inwardly rectifying K+ conductance. Reduction of the inwardly rectifying K+ conductance was mediated by a pertussis toxin-insensitive G protein.

MeSH Terms
Animals Cells, Cultured Cholinergic Fibers/drug effects Electric Conductivity GTP-Binding Proteins/drug effects,metabolism Guanosine Triphosphate/analogs & derivatives Ions Membrane Potentials Microelectrodes Neurons/drug effects Neurotensin/pharmacology Pertussis Toxin Potassium/metabolism Rats Signal Transduction Substantia Innominata/cytology,drug effects Virulence Factors, Bordetella/pharmacology
Chemicals
Ions Virulence Factors, Bordetella Neurotensin Guanosine Triphosphate Pertussis Toxin GTP-Binding Proteins Potassium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Farkas R H
Department of Anatomy and Cell Biology, University of Illinois, College of Medicine at Chicago 60612.
Nakajima S
Nakajima Y
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.7.2853
Published
1994-03-29
Pages
2853-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC43469
Subset
IM
Grants
NIA NIH HHS · AG06093 · United States
NIMH NIH HHS · F30MH10167 · United States
External Links
PubMed source DOI: 10.1073/pnas.91.7.2853 PMC Full Text View journal details
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