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PMID: 8143344 Published · ppublish English Journal Article Review

Calcium-mediated signal transduction: biology, biochemistry, and therapy.

Cancer metastasis reviews ·Vol. 13 ·No. 1 ·1994-03-00 ·Pages 31-44

Cole K, Kohn E

Abstract

The process of proliferation, invasion and metastasis is a complex one which involves both the autonomy of the malignant cells and their interaction with the cellular and extracellular environments. The way in which the tumor cells respond to cellular and extracellular stimuli is regulated through transduction of those signals and translation into cellular activity. Transmembrane signal transduction involves three major categories of events: ion channel activation, transmission through guanine nucleotide binding protein intermediates with production of second messengers, and phosphorylation events. A frequent common denominator of these different pathways is a cellular calcium homeostasis. Calcium may be both a result of and a regulator of many of these signal transduction pathways and has been shown to have a role in the regulation of proliferation, invasion, and metastatic potential. The understanding and application of the basic tenets of these pathways to tumor cell proliferation, invasion, and metastases opens a new target for therapeutic intervention. We have identified a novel agent, CAI, which through inhibition of stimulated calcium influx inhibits proliferation and migration in vitro, and growth and dissemination in human cancer xenografts in vivo. CAI offers a new approach to cancer therapy, signal transduction therapy.

MeSH Terms
Animals Calcium/metabolism,physiology Cell Adhesion Cell Division Cell Movement GTP-Binding Proteins/physiology Humans Neoplasm Invasiveness Neoplasm Metastasis Neoplasms/metabolism,pathology,physiopathology,therapy Signal Transduction
Chemicals
GTP-Binding Proteins Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cole K
Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892.
Kohn E
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Article Info
Journal
Cancer metastasis reviews
Abbr.
Cancer Metastasis Rev
ISSN
0167-7659
DOI
10.1007/BF00690417
Published
1994-03-00
Pages
31-44
Language
English
Region
Netherlands
NLM ID
8605731
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00690417 View journal details
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