Home LiteratureArticle Details
PMID: 8137819 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

STF-IL-4: a novel IL-4-induced signal transducing factor.

The EMBO journal ·Vol. 13 ·No. 6 ·1994-03-15 ·Pages 1350-6

Schindler C, Kashleva H, Pernis A, Pine R, Rothman P

Abstract

The mechanism by which interleukin-4 (IL-4) regulates the expression of particular genes is unknown. We have determined that IL-4 induces a DNA binding factor (termed STF-IL-4) which has a strong affinity for an IFN-gamma activation site (GAS). Interestingly, STF-IL-4 also binds to the IL-4 responsive promoter for the Ig heavy chain germline epsilon transcript. The IL-4 dependent activation of STF-IL-4 is rapid, does not require protein synthesis and results in the sequential appearance of binding activity first in the cytoplasm and then later in the nucleus. Activation of STF-IL-4 is sensitive to tyrosine kinase inhibitors and the active factor is tyrosine phosphorylated. This pattern of activation is similar to the activation of interferon-induced transcription factors. STF-IL-4 appears to be a new member of a growing family of cytokine-induced transcriptional regulators.

MeSH Terms
Animals Base Sequence Biological Transport Cell Nucleus/metabolism Cells, Cultured Cytoplasm/metabolism DNA/metabolism DNA-Binding Proteins/biosynthesis,metabolism Gene Expression Regulation Immunoglobulins/metabolism Interleukin-4/physiology Mice Molecular Sequence Data Phosphorylation Promoter Regions, Genetic Signal Transduction Tyrosine/metabolism
Chemicals
DNA-Binding Proteins Immunoglobulins Interleukin-4 Tyrosine DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Schindler C
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Kashleva H
Pernis A
Pine R
Rothman P
References (43)
43 references, click to expand
  1. Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line.
    Nature. 1982 Mar 25;296(5855):325-31 PMID: 6801527
  2. A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter.
    Mol Cell Biol. 1993 Jan;13(1):690-702 PMID: 7678055
  3. Interleukin-induced increase in Ia expression by normal mouse B cells.
    J Exp Med. 1984 Sep 1;160(3):679-94 PMID: 6432933
  4. Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.
    Proc Natl Acad Sci U S A. 1984 Oct;81(19):6149-53 PMID: 6435125
  5. BSF-1 action on resting B cells does not require elevation of inositol phospholipid metabolism or increased [Ca2+]i.
    J Immunol. 1986 Oct 1;137(7):2215-9 PMID: 3093568
  6. BSF1 induces membrane protein phosphorylation but not phosphoinositide metabolism, Ca2+ mobilization, protein kinase C translocation, or membrane depolarization in resting murine B lymphocytes.
    J Immunol. 1986 Dec 1;137(11):3664-70 PMID: 3023486
  7. Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes.
    J Exp Med. 1987 Jun 1;165(6):1459-67 PMID: 2953844
  8. B-cell stimulatory factor-1/interleukin 4.
    Annu Rev Immunol. 1987;5:429-59 PMID: 3297106
  9. Murine B-cell stimulatory factor 1 (interleukin 4) increases expression of the Fc receptor for IgE on mouse B cells.
    Proc Natl Acad Sci U S A. 1987 Jul;84(13):4606-10 PMID: 2955412
  10. Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.
    Genes Dev. 1988 Apr;2(4):383-93 PMID: 3371658
  11. Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.
    Proc Natl Acad Sci U S A. 1988 Oct;85(20):7704-8 PMID: 2459714
  12. Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells.
    J Exp Med. 1988 Dec 1;168(6):2385-9 PMID: 3264328
  13. Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma.
    Proc Natl Acad Sci U S A. 1989 Apr;86(8):2829-33 PMID: 2495537
  14. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
    Annu Rev Immunol. 1989;7:145-73 PMID: 2523712
  15. Rapid induction of transcription of unrearranged S gamma 1 switch regions in activated murine B cells by interleukin 4.
    EMBO J. 1989 Feb;8(2):483-8 PMID: 2785916
  16. Induction of c-fos and c-myc expression during B cell activation by IL-4 and immunoglobulin binding ligands.
    J Immunol. 1989 Aug 1;143(3):1032-9 PMID: 2787345
  17. Structure and expression of germ line immunoglobulin heavy-chain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon.
    Mol Cell Biol. 1990 Apr;10(4):1672-9 PMID: 2157139
  18. Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts.
    Mol Cell Biol. 1991 Nov;11(11):5551-61 PMID: 1922063
  19. Generation and analysis of interleukin-4 deficient mice.
    Science. 1991 Nov 1;254(5032):707-10 PMID: 1948049
  20. High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons.
    Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11455-9 PMID: 1837150
  21. Cell-free activation of a DNA-binding protein by epidermal growth factor.
    Nature. 1993 Mar 4;362(6415):79-83 PMID: 7680434
  22. The response of gamma interferon activation factor is under developmental control in cells of the macrophage lineage.
    Mol Cell Biol. 1993 Jun;13(6):3245-54 PMID: 8497250
  23. The hematopoietin receptor superfamily.
    Cytokine. 1993 Mar;5(2):95-106 PMID: 8392875
  24. Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds.
    Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6806-10 PMID: 7688129
  25. The gene encoding IFP 53/tryptophanyl-tRNA synthetase is regulated by the gamma-interferon activation factor.
    J Biol Chem. 1993 Aug 5;268(22):16590-5 PMID: 8344940
  26. Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.
    Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8429-33 PMID: 8378315
  27. Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation.
    Science. 1993 Sep 24;261(5129):1736-9 PMID: 8378775
  28. A common nuclear signal transduction pathway activated by growth factor and cytokine receptors.
    Science. 1993 Sep 24;261(5129):1739-44 PMID: 8397445
  29. Mechanism and regulation of immunoglobulin isotype switching.
    Adv Immunol. 1993;54:229-70 PMID: 8379463
  30. Early events in signalling by interferons.
    Trends Biochem Sci. 1993 Sep;18(9):338-42 PMID: 7694399
  31. Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus.
    Science. 1993 Dec 3;262(5139):1575-9 PMID: 7504325
  32. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.
    Science. 1994 Jan 7;263(5143):89-92 PMID: 8272872
  33. Structure of the IL4 receptor and signal transduction mechanism of IL4.
    Res Immunol. 1993 Oct;144(8):584-90 PMID: 8303077
  34. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.
    EMBO J. 1994 Jan 1;13(1):158-67 PMID: 8306959
  35. Sequences and factors: a guide to MHC class-II transcription.
    Annu Rev Immunol. 1992;10:13-49 PMID: 1590984
  36. Cytokine receptors and signal transduction.
    Annu Rev Immunol. 1992;10:295-331 PMID: 1590989
  37. Mammary gland-specific nuclear factor is present in lactating rodent and bovine mammary tissue and composed of a single polypeptide of 89 kDa.
    J Biol Chem. 1992 Aug 15;267(23):16365-70 PMID: 1644820
  38. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor.
    Science. 1992 Aug 7;257(5071):809-13 PMID: 1496401
  39. Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.
    Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7836-9 PMID: 1502203
  40. IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells.
    EMBO J. 1992 Dec;11(13):4899-908 PMID: 1334461
  41. Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein.
    Science. 1992 Dec 11;258(5089):1808-12 PMID: 1281555
  42. Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.
    Mol Cell Biol. 1993 Jan;13(1):276-88 PMID: 7678052
  43. I region-restricted antigen presentation by B cell-B lymphoma hybridomas.
    Nature. 1982 Jul 15;298(5871):283-4 PMID: 6211627
Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1994-03-15
Pages
1350-6
Language
English
Region
England
NLM ID
8208664
PMCID
PMC394951
Subset
IM
Grants
NIAID NIH HHS · AI 33450-01 · United States
NHLBI NIH HHS · HL 21006-17 · United States
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2