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PMID: 8107202 Published · ppublish English Journal Article

Borna disease virus (BDV), a nonsegmented RNA virus, replicates in the nuclei of infected cells where infectious BDV ribonucleoproteins are present.

Journal of virology ·Vol. 68 ·No. 3 ·1994-03-00 ·Pages 1371-81

Cubitt B, de la Torre JC

Abstract

Borna disease virus (BDV) causes neurological disease in a wide range of animal species, providing an important model for studies of persistent viral infection of the central nervous system. In addition, the detection of antibodies that react with BDV antigen in serum from psychiatric patients suggests a role for BDV, or related viruses, in human mental disorders, providing further reason for study of this poorly characterized neurotropic virus. We present evidence that BDV has a nonsegmented negative single-strand RNA genome with the property that viral replication and transcription take place in the nuclei of infected cells where infectious BDV ribonucleoproteins are present. Our results support the view that BDV has unique biological features among animal viruses. Furthermore, the finding that BDV ribonucleoproteins are able to infect susceptible cells raises interesting questions regarding the mechanisms by which some neurotropic viruses may spread through the central nervous system of the infected host without requiring the production of mature infectious virus.

MeSH Terms
Animals Antigens, Viral/analysis Base Sequence Borna disease virus/growth & development Brain/microbiology Cell Compartmentation Cell Nucleus/chemistry,microbiology Gene Expression Genome, Viral Molecular Sequence Data Neuroglia/microbiology RNA, Viral/biosynthesis Rats Ribonucleoproteins/analysis Subcellular Fractions Transfection Virus Replication
Chemicals
Antigens, Viral RNA, Viral Ribonucleoproteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cubitt B
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037.
de la Torre J C
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.68.3.1371-1381.1994
Published
1994-03-00
Pages
1371-81
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC236591
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.68.3.1371-1381.1994 PMC Full Text View journal details
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