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PMID: 1454837 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 89 ·No. 23 ·1992-12-01 ·Pages 11486-9

Briese T, de la Torre JC, Lewis A, Ludwig H, Lipkin WI

Abstract

Borna disease virus, an unclassified infectious agent, causes immune-mediated neurologic disease in a wide variety of animal hosts and may be involved in pathogenesis of selected neuropsychiatric diseases in man. Initial reports suggested that Borna disease virus is a single-stranded RNA virus. We describe here a method for isolation of viral particles that has allowed definitive identification of the genome as containing a negative-polarity RNA. Further, we show that the viral mRNAs are transcribed in the nucleus.

MeSH Terms
Borna disease virus/genetics Cell Nucleus/microbiology Cells, Cultured Humans In Vitro Techniques Protein Biosynthesis RNA Viruses/genetics RNA, Messenger/genetics RNA, Viral/genetics Transcription, Genetic Virus Diseases/genetics
Chemicals
RNA, Messenger RNA, Viral
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Briese T
Institute of Virology, Free University of Berlin, Federal Republic of Germany.
de la Torre J C
Lewis A
Ludwig H
Lipkin W I
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.89.23.11486
Published
1992-12-01
Pages
11486-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC50576
Subset
IM
Grants
NINDS NIH HHS · NS-12428 · United States
NINDS NIH HHS · NS-29425 · United States
External Links
PubMed source DOI: 10.1073/pnas.89.23.11486 PMC Full Text View journal details
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