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PMID: 8103991 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Gene expression and chemical diversity in hypothalamic neurosecretory neurons.

Molecular neurobiology ·Vol. 7 ·No. 2 ·1993-00-00 ·Pages 87-110

Meister B

Abstract

Hypothalamic neurosecretory neurons transcribe, translate, store, and secrete a large number of chemical messengers. The neurons contain hypothalamic signal substances that regulate the secretion of anterior pituitary hormones as well as the neurohypophysial peptides vasopressin and oxytocin. In addition to the classical hypophysiotropic hormones, a large number of neuropeptides and classical transmitters of amine and amino acid nature are present in the same cells. This is particularly evident in the magnocellular neurons of the supraoptic and paraventricular nuclei, and in parvocellular neurons of the arcuate and paraventricular nuclei. The changes in gene expression induced by experimental manipulations and the colocalization chemical messengers in hypothalamic neurosecretory neurons and its possible significance is summarized in this review.

MeSH Terms
Animals Aspartic Acid/physiology Gene Expression Regulation Glutamates/physiology Glutamic Acid Humans Hypophysectomy Hypothalamic Hormones/biosynthesis,genetics,metabolism Hypothalamo-Hypophyseal System/physiology Hypothalamus/anatomy & histology,cytology,metabolism Neurons/metabolism Neuropeptides/biosynthesis,genetics,metabolism Neurotransmitter Agents/biosynthesis,metabolism Osmolar Concentration Rats Rats, Brattleboro/physiology Sodium Glutamate/toxicity
Chemicals
Glutamates Hypothalamic Hormones Neuropeptides Neurotransmitter Agents Aspartic Acid Glutamic Acid Sodium Glutamate
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Meister B
Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
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Article Info
Journal
Molecular neurobiology
Abbr.
Mol Neurobiol
ISSN
0893-7648
DOI
10.1007/BF02935638
Published
1993-00-00
Pages
87-110
Language
English
Region
United States
NLM ID
8900963
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02935638 View journal details
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