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PMID: 8101988 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 90 ·No. 14 ·1993-07-15 ·Pages 6381-4

Price DL, Borchelt DR, Sisodia SS

Abstract

Alzheimer disease and the prion disorders/spongiform encephalopathies share many common features. These chronic, progressive, sometimes familial diseases of the central nervous system are characterized by the presence of different types of amyloid deposits in the brain. This review provides a perspective on these two types of neurodegenerative disorders.

MeSH Terms
Alzheimer Disease/genetics,metabolism,pathology Amyloid beta-Peptides/metabolism Amyloidosis/pathology Humans PrPSc Proteins Prion Diseases/genetics,metabolism,pathology Prions/metabolism
Chemicals
Amyloid beta-Peptides PrPSc Proteins Prions
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Price D L
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196.
Borchelt D R
Sisodia S S
References (90)
90 references, click to expand
  1. Mutation in codon 200 of scrapie amyloid protein gene in two clusters of Creutzfeldt-Jakob disease in Slovakia.
    Lancet. 1990 Aug 25;336(8713):514-5 PMID: 1975028
  2. Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.
    Cell. 1990 Nov 16;63(4):673-86 PMID: 1977523
  3. Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits.
    Am J Pathol. 1990 Dec;137(6):1383-92 PMID: 1701963
  4. Spontaneous neurodegeneration in transgenic mice with mutant prion protein.
    Science. 1990 Dec 14;250(4987):1587-90 PMID: 1980379
  5. New mutation in scrapie amyloid precursor gene (at codon 178) in Finnish Creutzfeldt-Jakob kindred.
    Lancet. 1991 Feb 16;337(8738):425 PMID: 1671440
  6. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.
    Science. 1991 Feb 8;251(4994):675-8 PMID: 1899488
  7. Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis.
    J Virol. 1991 Mar;65(3):1340-51 PMID: 1704926
  8. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
    Nature. 1991 Feb 21;349(6311):704-6 PMID: 1671712
  9. Amyloid precursor protein in aged nonhuman primates.
    Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1461-5 PMID: 1899927
  10. Mutation of the prion protein in Libyan Jews with Creutzfeldt-Jakob disease.
    N Engl J Med. 1991 Apr 18;324(16):1091-7 PMID: 2008182
  11. The molecular pathology of Alzheimer's disease.
    Neuron. 1991 Apr;6(4):487-98 PMID: 1673054
  12. Patterns of aberrant sprouting in Alzheimer's disease.
    Neuron. 1991 May;6(5):729-39 PMID: 1827266
  13. A prion protein variant in a family with the telencephalic form of Gerstmann-Sträussler-Scheinker syndrome.
    Neurology. 1991 May;41(5):681-4 PMID: 1674116
  14. Molecular biology of prion diseases.
    Science. 1991 Jun 14;252(5012):1515-22 PMID: 1675487
  15. The possible role of adhesion in synaptic modification.
    Trends Neurosci. 1991 Apr;14(4):127-30 PMID: 1710846
  16. Alzheimer's disease affects limbic nuclei of the thalamus.
    Acta Neuropathol. 1991;81(3):261-8 PMID: 1711755
  17. Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition.
    Science. 1991 Jul 12;253(5016):179-82 PMID: 1853202
  18. Formation of beta-amyloid protein deposits in brains of transgenic mice.
    Nature. 1991 Jul 18;352(6332):239-41 PMID: 1906990
  19. Deposits of amyloid beta protein in the central nervous system of transgenic mice.
    Science. 1991 Jul 19;253(5017):323-5 PMID: 1857970
  20. Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.
    Lancet. 1991 Apr 20;337(8747):978-9 PMID: 1678058
  21. Secretion of the beta/A4 amyloid precursor protein. Identification of a cleavage site in cultured mammalian cells.
    J Biol Chem. 1991 Sep 5;266(25):16960-4 PMID: 1909332
  22. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease.
    Science. 1991 Oct 4;254(5028):97-9 PMID: 1925564
  23. Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene.
    Nature. 1991 Oct 31;353(6347):844-6 PMID: 1944558
  24. Amyloid plaques, neurofibrillary tangles and neuronal loss in brains of transgenic mice overexpressing a C-terminal fragment of human amyloid precursor protein.
    Nature. 1991 Dec 12;354(6353):476-8 PMID: 1793460
  25. Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.
    J Biol Chem. 1992 Jan 5;267(1):546-54 PMID: 1730616
  26. Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene.
    N Engl J Med. 1992 Feb 13;326(7):444-9 PMID: 1346338
  27. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
    Science. 1992 Feb 7;255(5045):728-30 PMID: 1738847
  28. In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease beta-protein.
    Biochem Biophys Res Commun. 1986 Dec 15;141(2):782-9 PMID: 3541938
  29. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment.
    Ann Neurol. 1991 Oct;30(4):572-80 PMID: 1789684
  30. Deposition of beta/A4 protein along neuronal plasma membranes in diffuse senile plaques.
    Acta Neuropathol. 1991;83(1):21-9 PMID: 1724335
  31. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein.
    Nature. 1992 Apr 16;356(6370):577-82 PMID: 1373228
  32. Genetic association and linkage analysis of the apolipoprotein CII locus and familial Alzheimer's disease.
    Ann Neurol. 1992 Feb;31(2):223-7 PMID: 1349467
  33. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.
    Nature. 1992 Jun 11;357(6378):500-3 PMID: 1608449
  34. Beta-amyloid precursor protein cleavage by a membrane-bound protease.
    Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6075-9 PMID: 1631093
  35. Phenotypic characteristics of familial Creutzfeldt-Jakob disease associated with the codon 178Asn PRNP mutation.
    Ann Neurol. 1992 Mar;31(3):282-5 PMID: 1353342
  36. Evidence for synthesis of scrapie prion proteins in the endocytic pathway.
    J Biol Chem. 1992 Aug 15;267(23):16188-99 PMID: 1353761
  37. The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.
    Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5066-70 PMID: 8506352
  38. Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices.
    Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5191-3 PMID: 8506366
  39. Molecular biology and pathology of scrapie and the prion diseases of humans.
    Brain Pathol. 1991 Jul;1(4):297-310 PMID: 1669719
  40. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.
    Cell. 1989 Apr 7;57(1):115-26 PMID: 2649245
  41. Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.
    Science. 1987 Feb 20;235(4791):873-7 PMID: 3544219
  42. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
    Nature. 1987 Feb 19-25;325(6106):733-6 PMID: 2881207
  43. Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.
    Proc Natl Acad Sci U S A. 1987 Oct;84(19):6953-7 PMID: 3477820
  44. Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome.
    Nature. 1989 Mar 23;338(6213):342-5 PMID: 2564168
  45. Experimental transmission of a Kuru-like syndrome to chimpanzees.
    Nature. 1966 Feb 19;209(5025):794-6 PMID: 5922150
  46. Creutzfeldt-Jakob disease (spongiform encephalopathy): transmission to the chimpanzee.
    Science. 1968 Jul 26;161(3839):388-9 PMID: 5661299
  47. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain.
    Science. 1982 Mar 5;215(4537):1237-9 PMID: 7058341
  48. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.
    Biochem Biophys Res Commun. 1984 May 16;120(3):885-90 PMID: 6375662
  49. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.
    Neurology. 1984 Jul;34(7):939-44 PMID: 6610841
  50. Amyloid plaque core protein in Alzheimer disease and Down syndrome.
    Proc Natl Acad Sci U S A. 1985 Jun;82(12):4245-9 PMID: 3159021
  51. Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.
    EMBO J. 1985 Nov;4(11):2757-63 PMID: 4065091
  52. Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer's disease.
    Nature. 1986 Feb 13-19;319(6054):593-5 PMID: 3003585
  53. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.
    J Biol Chem. 1986 May 5;261(13):6084-9 PMID: 3084478
  54. Amyloid plaques in Creutzfeldt-Jakob disease stain with prion protein antibodies.
    Ann Neurol. 1986 Aug;20(2):204-8 PMID: 3092727
  55. Perforant pathway changes and the memory impairment of Alzheimer's disease.
    Ann Neurol. 1986 Oct;20(4):472-81 PMID: 3789663
  56. Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.
    N Engl J Med. 1989 Jun 1;320(22):1446-52 PMID: 2566117
  57. Mutations in familial Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker's syndrome.
    Exp Neurol. 1989 Nov;106(2):204-6 PMID: 2572450
  58. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported.
    JAMA. 1989 Nov 10;262(18):2551-6 PMID: 2810583
  59. Gerstmann-Sträussler-Scheinker disease. II. Neurofibrillary tangles and plaques with PrP-amyloid coexist in an affected family.
    Neurology. 1989 Nov;39(11):1453-61 PMID: 2573006
  60. Evidence for lysosomal processing of amyloid beta-protein precursor in cultured cells.
    Neurochem Res. 1989 Oct;14(10):933-9 PMID: 2514387
  61. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.
    Proc Natl Acad Sci U S A. 1990 Feb;87(4):1561-5 PMID: 1689489
  62. Amyloid beta-peptide is produced by cultured cells during normal metabolism.
    Nature. 1992 Sep 24;359(6393):322-5 PMID: 1383826
  63. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids.
    Nature. 1992 Sep 24;359(6393):325-7 PMID: 1406936
  64. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors.
    Science. 1992 Oct 9;258(5080):304-7 PMID: 1411529
  65. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14.
    Science. 1992 Oct 23;258(5082):668-71 PMID: 1411576
  66. Amyloidosis in aging and Alzheimer's disease.
    Am J Pathol. 1992 Oct;141(4):767-72 PMID: 1415474
  67. Amyloidogenesis in Alzheimer's disease: basic biology and animal models.
    Curr Opin Neurobiol. 1992 Oct;2(5):648-52 PMID: 1422121
  68. An insert mutation in the chromosome 20 amyloid precursor gene in a Gerstmann-Sträussler-Scheinker family.
    J Neurol Sci. 1992 Sep;111(2):189-94 PMID: 1431985
  69. Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.
    Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10857-61 PMID: 1438289
  70. Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.
    Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10940-4 PMID: 1438300
  71. Production of the Alzheimer amyloid beta protein by normal proteolytic processing.
    Science. 1992 Oct 2;258(5079):126-9 PMID: 1439760
  72. Toxicity of synthetic A beta peptides and modeling of Alzheimer's disease.
    Neurobiol Aging. 1992 Sep-Oct;13(5):623-5 PMID: 1461354
  73. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
    Nature. 1992 Dec 17;360(6405):672-4 PMID: 1465129
  74. Neuronal degeneration in human diseases and animal models.
    J Neurobiol. 1992 Nov;23(9):1277-94 PMID: 1469388
  75. Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.
    Science. 1993 Jan 22;259(5094):514-6 PMID: 8424174
  76. Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)
    Nature. 1993 Mar 4;362(6415):75-9 PMID: 8446172
  77. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
    Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1977-81 PMID: 8446617
  78. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.
    Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2092-6 PMID: 8446635
  79. Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing.
    Biochemistry. 1993 Mar 2;32(8):1991-2002 PMID: 8448158
  80. Altered processing of Alzheimer amyloid precursor protein in response to neuronal degeneration.
    Proc Natl Acad Sci U S A. 1993 May 1;90(9):4146-50 PMID: 8483927
  81. Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles.
    Nat Genet. 1992 Apr;1(1):68-71 PMID: 1363810
  82. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.
    Nat Genet. 1992 Jun;1(3):218-21 PMID: 1303239
  83. Synthetic peptides corresponding to different mutated regions of the amyloid gene in familial Creutzfeldt-Jakob disease show enhanced in vitro formation of morphologically different amyloid fibrils.
    Proc Natl Acad Sci U S A. 1993 May 15;90(10):4451-4 PMID: 8506284
  84. Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth.
    Proc Natl Acad Sci U S A. 1993 May 15;90(10):4748-52 PMID: 8506329
  85. Epitopes that span the tau molecule are shared with paired helical filaments.
    Neuron. 1988 Nov;1(9):817-25 PMID: 2483104
  86. Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates.
    Neuron. 1990 Jan;4(1):97-104 PMID: 2106906
  87. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing.
    Science. 1990 Apr 27;248(4954):492-5 PMID: 1691865
  88. Cleavage of amyloid beta peptide during constitutive processing of its precursor.
    Science. 1990 Jun 1;248(4959):1122-4 PMID: 2111583
  89. A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.
    Proc Natl Acad Sci U S A. 1990 Aug;87(15):5827-31 PMID: 2116006
  90. Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.
    Proc Natl Acad Sci U S A. 1990 Aug;87(15):6003-6 PMID: 2116015
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.90.14.6381
Published
1993-07-15
Pages
6381-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC46935
Subset
IM
Grants
NIA NIH HHS · AG 05146 · United States
NINDS NIH HHS · NS 07179 · United States
NINDS NIH HHS · NS 20471 · United States
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1073/pnas.90.14.6381 PMC Full Text View journal details
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