Statistical analysis of nucleotide sequences of the hemagglutinin gene of human influenza A viruses.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 18 ·1994-08-30 ·Pages 8388-92

Ina Y, Gojobori T

Abstract

To examine whether positive selection operates on the hemagglutinin 1 (HA1) gene of human influenza A viruses (H1 subtype), 21 nucleotide sequences of the HA1 gene were statistically analyzed. The nucleotide sequences were divided into antigenic and nonantigenic sites. The nucleotide diversities for antigenic and nonantigenic sites of the HA1 gene were computed at synonymous and nonsynonymous sites separately. For nonantigenic sites, the nucleotide diversities were larger at synonymous sites than at nonsynonymous sites. This is consistent with the neutral theory of molecular evolution. For antigenic sites, however, the nucleotide diversities at nonsynonymous sites were larger than those at synonymous sites. These results suggest that positive selection operates on antigenic sites of the HA1 gene of human influenza A viruses (H1 subtype).

Related Genes

HA1

MeSH Terms

Antigens, Viral/genetics Base Sequence DNA, Viral/genetics Genes, Viral Hemagglutinins, Viral/genetics Influenza A virus/genetics Molecular Sequence Data Sequence Homology, Nucleic Acid Viral Structural Proteins/genetics

Chemicals

Antigens, Viral DNA, Viral Hemagglutinins, Viral Viral Structural Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Ina Y

National Institute of Genetics, Mishima, Japan.

Gojobori T

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31 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.91.18.8388

Published

1994-08-30

Pages

8388-92

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC44611

Subset

Databases

GENBANK

D13573, D13574, X59778

External Links

PubMed source DOI: 10.1073/pnas.91.18.8388 PMC Full Text View journal details

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Statistical analysis of nucleotide sequences of the hemagglutinin gene of human influenza A viruses.

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