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PMID: 6634412 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Antigenicity and evolution amongst recent influenza viruses of H1N1 subtype.

Nucleic acids research ·Vol. 11 ·No. 20 ·1983-10-25 ·Pages 7191-203

Raymond FL, Caton AJ, Cox NJ, Kendal AP, Brownlee GG

Abstract

The sequence of the HA1 subunit region of the haemagglutinin gene of influenza A/USSR/90/77, and A/Brazil/11/78, A/Lackland/3/78, A/England/333/80 and A/India/6263/80 was determined by dideoxy-sequencing methods using total virion RNA and specific oligonucleotide primers for reverse transcriptase. These 1977-1980 strains share a minimum of 85% amino acid sequence homology with influenza A/PR/8/34. Most of the surface amino acid substitutions which occurred during the evolution of A/PR/8/34 to A/USSR/90/77 and subsequently in the 1978-1980 strains are located in the 4 antigenic sites previously defined by an analysis of laboratory-selected mutants of A/PR/8/34. We deduce an evolutionary pathway for the 1977-80 strains and suggest their different epidemic properties may be a consequence of only a few amino acid changes.

MeSH Terms
Antigens, Viral/genetics Base Sequence Biological Evolution Hemagglutination, Viral Hemagglutinins, Viral/genetics Influenza A Virus, H1N1 Subtype Influenza A virus/genetics,immunology RNA, Viral/genetics Species Specificity Virion/genetics
Chemicals
Antigens, Viral Hemagglutinins, Viral RNA, Viral
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Raymond F L
Caton A J
Cox N J
Kendal A P
Brownlee G G
References (21)
21 references, click to expand
  1. Molecular mechanisms of variation in influenza viruses.
    Nature. 1982 Mar 11;296(5853):115-21 PMID: 6174870
  2. On the origin of the H1N1 (A/USSR/90/77) influenza virus.
    J Gen Virol. 1981 Oct;56(Pt 2):437-40 PMID: 7310382
  3. The sequence of RNA segment 1 of influenza virus A/NT/60/68 and its comparison with the corresponding segment of strains A/PR/8/34 and A/WSN/33.
    Nucleic Acids Res. 1983 Mar 11;11(5):1555-66 PMID: 6828387
  4. Laboratory-based surveillance of influenza A(H1N1) and A(H3N2) viruses in 1980-81: antigenic and genomic analyses.
    Bull World Health Organ. 1983;61(1):143-52 PMID: 6601537
  5. Evidence for host-cell selection of influenza virus antigenic variants.
    Nature. 1983 Jun 23-29;303(5919):706-9 PMID: 6190093
  6. Crystalline antigen from the influenza virus envelope.
    Nat New Biol. 1972 Aug 2;238(83):145-7 PMID: 4626449
  7. Properties of an antigenic glycoprotein isolated from influenza virus hemagglutinin.
    J Virol. 1973 Feb;11(2):183-92 PMID: 4688702
  8. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
  9. Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950.
    Nature. 1978 Jul 27;274(5669):334-9 PMID: 672956
  10. Antigenic similarity of influenza A (H1N1) viruses from epidemics in 1977--1978 to "Scandinavian" strains isolated in epidemics of 1950--1951.
    Virology. 1978 Sep;89(2):632-6 PMID: 82293
  11. Epidemiology of influenza in man.
    Br Med Bull. 1979 Jan;35(1):3-8 PMID: 367483
  12. Evolution of human influenza A viruses in nature: sequential mutations in the genomes of new H1N1.
    Cell. 1979 Sep;18(1):73-83 PMID: 509526
  13. Sequencing end-labeled DNA with base-specific chemical cleavages.
    Methods Enzymol. 1980;65(1):499-560 PMID: 6246368
  14. Cloning and DNA sequence of double-stranded copies of haemagglutinin genes from H2 and H3 strains elucidates antigenic shift and drift in human influenza virus.
    Nature. 1980 Sep 25;287(5780):301-6 PMID: 7421990
  15. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.
    Nature. 1981 Jan 29;289(5796):366-73 PMID: 7464906
  16. Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation.
    Nature. 1981 Jan 29;289(5796):373-8 PMID: 6162101
  17. Antigenic drift in the hemagglutinin of the Hong Kong influenza subtype: correlation of amino acid changes with alterations in viral antigenicity.
    J Virol. 1981 Mar;37(3):845-53 PMID: 6164798
  18. Complete sequence analysis shows that the hemagglutinins of the H0 and H2 subtypes of human influenza virus are closely related.
    Virology. 1981 May;111(1):113-24 PMID: 7233828
  19. Nucleotide sequence of the haemagglutinin gene of a human influenza virus H1 subtype.
    Nature. 1981 Jul 2;292(5818):72-5 PMID: 7278968
  20. Conservation and variation in the hemagglutinins of Hong Kong subtype influenza viruses during antigenic drift.
    J Virol. 1981 Sep;39(3):663-72 PMID: 6169840
  21. The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype).
    Cell. 1982 Dec;31(2 Pt 1):417-27 PMID: 6186384
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/11.20.7191
Published
1983-10-25
Pages
7191-203
Language
English
Region
England
NLM ID
0411011
PMCID
PMC326454
Subset
IM
Databases
GENBANK
X00027, X00028, X00029, X00030, X00031
External Links
PubMed source DOI: 10.1093/nar/11.20.7191 PMC Full Text View journal details
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