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PMID: 807554 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Plasmid deoxyribonucleic acid in clinical isolates of Neisseria gonorrhoeae.

Journal of bacteriology ·Vol. 122 ·No. 3 ·1975-06-00 ·Pages 1293-300

Stiffler PW, Lerner SA, Bohnhoff M, Morello JA

Abstract

Two different sizes of circular covalently closed deoxyribonucleic acid plasmids have been identified in four independent clinical isolates of Neisseria gonorrhoeae. All four strains contained a small plasmid with a molecular weight of 2.8 X 10-6 and two of the four stains also contained a large plasmid with a molecular weight of 24.5 X 10-6. The avirulent derivative of each of these four strains had the same plasmid complement as its virulent parent. There was no correlation between the presence of these plasmids and antibiotic resistance, piliation, and colony type associated with virulence, or ability to grow without seven specific amino acid supplements.

MeSH Terms
Amino Acids/metabolism Anti-Bacterial Agents/pharmacology Centrifugation, Density Gradient DNA, Bacterial/analysis DNA, Circular/analysis Drug Resistance, Microbial Extrachromosomal Inheritance Gonorrhea/microbiology Humans Microscopy, Electron Molecular Weight Neisseria gonorrhoeae/chemistry,drug effects,metabolism Ultracentrifugation
Chemicals
Amino Acids Anti-Bacterial Agents DNA, Bacterial DNA, Circular
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Stiffler P W
Lerner S A
Bohnhoff M
Morello J A
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33 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.122.3.1293-1300.1975
Published
1975-06-00
Pages
1293-300
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC246187
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.122.3.1293-1300.1975 PMC Full Text View journal details
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