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PMID: 805083 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

A possible role of repetitious DNA in recombinatory joining during chromosome rearrangement in Drosophila melanogaster.

Genetics ·Vol. 79 ·No. 3 ·1975-03-00 ·Pages 467-70

Lee CS

Abstract

It is postulated that certain repetitious DNA components play a role in the recombination processes during chromoxome reappangements. When the distribution of silver grain densities after the in situ hybridization of repetitious DNA (RUDKIN and TARTOF 1973) and the distribution of chromosome breaks due to X-irradiation (KAUFMANN 1946) are compared, a strong correlation is found for the euchromatic portion of the D. melanogaster salivary X chromosome. These observations justify the postulate above that certain repetitious DNA provides homologous regions in the DNA of broken chromosome ends necessary for proper recombinatory joining.

MeSH Terms
Animals Base Sequence Chromosome Aberrations Chromosome Mapping Chromosomes/radiation effects DNA/physiology Drosophila melanogaster/physiology,radiation effects,ultrastructure Female Male Nucleic Acid Hybridization Radiation Genetics Recombination, Genetic X-Rays
Chemicals
DNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Lee C S
References (5)
5 references, click to expand
  1. Distribution of Induced Breaks along the X-Chromosome of Drosophila Melanogaster.
    Proc Natl Acad Sci U S A. 1939 Nov;25(11):571-7 PMID: 16577949
  2. The one band-one gene hypothesis: evidence from a cytogenetic analysis of mutant and nonmutant rearrangement breadpoints in Drosophila melanogaster.
    Cold Spring Harb Symp Quant Biol. 1974;38:591-9 PMID: 4208794
  3. Isolation and chromosomal localization of highly repeated DNA sequences in Drosophila melanogaster.
    Proc Natl Acad Sci U S A. 1971 Jun;68(6):1125-9 PMID: 5001499
  4. Repetitious DNA.
    Adv Cell Biol. 1971;2:153-223 PMID: 4949653
  5. Reptitive DNA sequences in drosophila.
    Chromosoma. 1971;33(3):319-44 PMID: 5088497
Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/79.3.467
Published
1975-03-00
Pages
467-70
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1213286
Subset
IM
External Links
PubMed source DOI: 10.1093/genetics/79.3.467 PMC Full Text View journal details
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