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PMID: 8041794 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 15 ·1994-07-19 ·Pages 7355-9

Kliewer SA, Forman BM, Blumberg B, Ong ES, Borgmeyer U, Mangelsdorf DJ, Umesono K, Evans RM

Abstract

To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPAR alpha-related cDNAs (designated PPAR gamma and -delta, respectively) from mouse. The three PPAR isoforms display widely divergent patterns of expression during embryogenesis and in the adult. Surprisingly, PPAR gamma and -delta are not activated by pirinixic acid (Wy 14,643), a potent peroxisome proliferator and activator of PPAR alpha. However, PPAR gamma and -delta are activated by the structurally distinct peroxisome proliferator LY-171883 and linoleic acid, respectively, indicating that each of the isoforms can act as a regulated activator of transcription. These data suggest that tissue-specific responsiveness to peroxisome proliferators, including certain fatty acids, is in part a consequence of differential expression of multiple, pharmacologically distinct PPAR isoforms.

MeSH Terms
Acetophenones/pharmacology Aging/metabolism Amino Acid Sequence Animals Base Sequence Blotting, Northern Cloning, Molecular DNA Embryo, Mammalian/metabolism Linoleic Acid Linoleic Acids/pharmacology Mice Molecular Sequence Data Receptors, Cytoplasmic and Nuclear/genetics,metabolism Tetrazoles/pharmacology Transcription Factors/genetics,metabolism
Chemicals
Acetophenones Linoleic Acids Receptors, Cytoplasmic and Nuclear Tetrazoles Transcription Factors LY 171883 DNA Linoleic Acid
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Kliewer S A
Salk Institute for Biological Studies, La Jolla, CA.
Forman B M
Blumberg B
Ong E S
Borgmeyer U
Mangelsdorf D J
Umesono K
Evans R M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.15.7355
Published
1994-07-19
Pages
7355-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC44398
Subset
IM
Databases
GENBANK
U10374, U10375
External Links
PubMed source DOI: 10.1073/pnas.91.15.7355 PMC Full Text View journal details
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