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PMID: 7986527 Published · ppublish English Journal Article Review

Retention and retrieval in the endoplasmic reticulum and the Golgi apparatus.

Current opinion in cell biology ·Vol. 6 ·No. 4 ·1994-08-00 ·Pages 517-21

Nilsson T, Warren G

Abstract

Resident proteins of the exocytic pathway contain at least two types of information in their primary sequence for determining their subcellular location. The first type of information is found at the carboxyl terminus of soluble proteins of the endoplasmic reticulum (ER) and in the cytoplasmic domain of some ER and Golgi membrane proteins. It acts as a retrieval signal, returning proteins that have left the compartment in which they reside. The second type of information has been found in the membrane-spanning domain of several ER and Golgi proteins and, though the mechanism by which it operates is still unclear, it acts as a retention signal, keeping the protein at a particular location within the organelle. The presence of both a retrieval signal and a retention signal in a trans-Golgi network resident protein suggests that more than one mechanism operates to ensure correct localization of resident proteins along the exocytic pathway.

MeSH Terms
Amino Acid Sequence Animals Endoplasmic Reticulum/metabolism Golgi Apparatus/metabolism Humans Intracellular Membranes/physiology Molecular Sequence Data Oligopeptides/metabolism Protein Sorting Signals/metabolism Protein Structure, Tertiary
Chemicals
Oligopeptides Protein Sorting Signals
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nilsson T
Cell Biology Laboratory, Imperial Cancer Research Fund, London, UK.
Warren G
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/0955-0674(94)90070-1
Published
1994-08-00
Pages
517-21
Language
English
Region
England
NLM ID
8913428
PMCID
PMC7134804
Subset
IM
External Links
PubMed source DOI: 10.1016/0955-0674(94)90070-1 PMC Full Text View journal details
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