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PMID: 7972095 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Molecular evolution of the MyoD family of transcription factors.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 24 ·1994-11-22 ·Pages 11522-6

Atchley WR, Fitch WM, Bronner-Fraser M

Abstract

Myogenesis in skeletal muscle is a cascade of developmental events whose initiation involves the MyoD family of transcription factors. Evolutionary analyses of amino acid sequences of this family of transcriptional activators suggest that the vertebrate genes MyoD1, myf-5, Myog (myogenin), and myf-6 were derived by gene duplications from a single ancestral gene. A common genetic origin predicts some functional redundancy between MyoD1 and myf-5 and between Myog and myf-6. Experimental studies have suggested that these pairs of genes can substitute for each other during myogenesis. Separate analyses of the conserved basic helix-loop-helix and nonconserved flanking elements yield similar branching sequences but show evolutionary change in the basic helix-loop-helix region has occurred at a much slower rate.

Related Genes
Myf5 MyoD1 Myog myf-5 myf-6
MeSH Terms
Animals Helix-Loop-Helix Motifs Humans MyoD Protein/genetics Phylogeny Sequence Homology, Amino Acid
Chemicals
MyoD Protein
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Atchley W R
Department of Genetics, North Carolina State University, Raleigh 27695-7614.
Fitch W M
Bronner-Fraser M
References (32)
32 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.24.11522
Published
1994-11-22
Pages
11522-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC45263
Subset
IM
Grants
NIGMS NIH HHS · GM-45344 · United States
NICHD NIH HHS · HD-15527 · United States
NICHD NIH HHS · HD-25138 · United States
External Links
PubMed source DOI: 10.1073/pnas.91.24.11522 PMC Full Text View journal details
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