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PMID: 2552320 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis.

Nature ·Vol. 341 ·No. 6240 ·1989-09-28 ·Pages 303-7

Sassoon D, Lyons G, Wright WE, Lin V, Lassar A, Weintraub H, Buckingham M

Abstract

MyoD1 and myogenin are muscle-specific proteins which can convert non-myogenic cells in culture to differentiated muscle fibres, implicating them in myogenic determination. The pattern of expression of MyoD1 and myogenin during the early stages of muscle formation in the mouse embryo in vivo and in limb-bud explants cultured in vitro, indicates that they may have different functions in different types of muscle during development.

MeSH Terms

Animals Cell Differentiation Cells, Cultured Cloning, Molecular DNA/genetics Embryonic and Fetal Development Muscle Proteins/analysis,biosynthesis,genetics Muscles/embryology MyoD Protein Myogenin Nuclear Proteins/analysis,biosynthesis,genetics Organ Culture Techniques Organ Specificity Phosphoproteins/analysis,biosynthesis,genetics RNA Probes RNA, Messenger/analysis Transcription, Genetic

Chemicals

Muscle Proteins MyoD Protein MyoD1 myogenic differentiation protein Myogenin Nuclear Proteins Phosphoproteins RNA Probes RNA, Messenger DNA

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Sassoon D

Department of Molecular Biology, Pasteur Institute, Paris, France.

Lyons G

Wright W E

Lin V

Lassar A

Weintraub H

Buckingham M

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/341303a0

Published

1989-09-28

Pages

303-7

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/341303a0 View journal details

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Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis.

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