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PMID: 7909602 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cell biological mechanisms of multidrug resistance in tumors.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 9 ·1994-04-26 ·Pages 3497-504

Simon SM, Schindler M

Abstract

Multidrug resistance (MDR) is a generic term for the variety of strategies tumor cells use to evade the cytotoxic effects of anticancer drugs. MDR is characterized by a decreased sensitivity of tumor cells not only to the drug employed for chemotherapy but also to a broad spectrum of drugs with neither obvious structural homology nor common targets. This pleiotropic resistance is one of the major obstacles to the successful treatment of tumors. MDR may result from structural or functional changes at the plasma membrane or within the cytoplasm, cellular compartments, or nucleus. Molecular mechanisms of MDR are discussed in terms of modifications in detoxification and DNA repair pathways, changes in cellular sites of drug sequestration, decreases in drug-target affinity, synthesis of specific drug inhibitors within cells, altered or inappropriate targeting of proteins, and accelerated removal or secretion of drugs.

Related Genes
MDR1
MeSH Terms
ATP Binding Cassette Transporter, Subfamily B, Member 1 Biological Transport, Active Carrier Proteins/physiology Cell Compartmentation Cell Membrane/physiology Cell Nucleus/physiology Drug Resistance Exocytosis Humans Hydrogen-Ion Concentration Membrane Glycoproteins/physiology Neoplasms/drug therapy
Chemicals
ATP Binding Cassette Transporter, Subfamily B, Member 1 Carrier Proteins Membrane Glycoproteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Simon S M
Laboratory of Cellular Biophysics, Rockefeller University, New York, NY 10021.
Schindler M
References (135)
135 references, click to expand
  1. Membrane potential differences between adriamycin-sensitive and -resistant cells as measured by flow cytometry.
    Biochem Pharmacol. 1989 Jan 15;38(2):305-12 PMID: 2914014
  2. Lipid sorting in epithelial cells.
    Biochemistry. 1988 Aug 23;27(17):6197-202 PMID: 3064805
  3. Depolarization-induced alkalinization in proximal tubules. I. Characteristics and dependence on Na+.
    Am J Physiol. 1989 Feb;256(2 Pt 2):F342-53 PMID: 2916666
  4. Depolarization-induced alkalinization in proximal tubules. II. Effects of lactate and SITS.
    Am J Physiol. 1989 Feb;256(2 Pt 2):F354-65 PMID: 2916667
  5. Increased cytosolic pH in multidrug-resistant human lung tumor cells: effect of verapamil.
    J Natl Cancer Inst. 1989 May 3;81(9):706-9 PMID: 2565404
  6. The surface charge of membranes modulates the interaction with the anthracycline daunomycin.
    Ann N Y Acad Sci. 1988;551:443-5 PMID: 3245677
  7. Isolation and analysis of the C-terminal signal directing export of Escherichia coli hemolysin protein across both bacterial membranes.
    EMBO J. 1989 Feb;8(2):595-605 PMID: 2656259
  8. Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells.
    Biochim Biophys Acta. 1973 Oct 25;323(3):466-83 PMID: 4796512
  9. Reduced permeability in CHO cells as a mechanism of resistance to colchicine.
    J Cell Physiol. 1974 Feb;83(1):103-16 PMID: 4855907
  10. Intracellular aspects of the process of protein synthesis.
    Science. 1975 Aug 1;189(4200):347-58 PMID: 1096303
  11. Modulation of membrane drug permeability in Chinese hamster ovary cells.
    Biochim Biophys Acta. 1976 Dec 14;455(3):900-12 PMID: 999943
  12. Transport and binding of daunorubicin, adriamycin, and rubidazone in Ehrlich ascites tumour cells.
    Biochem Pharmacol. 1977 Feb 1;26(3):215-22 PMID: 14644
  13. The interaction of adriamycin and its beta anomer with DNA.
    Biochim Biophys Acta. 1977 May 3;476(1):38-46 PMID: 856282
  14. Correlation of biologic data with physico-chemical properties among the vinca alkaloids and their congeners.
    Biochem Pharmacol. 1977 Jul 1;26(13):1213-9 PMID: 18155
  15. Physical-chemical study of daunomycin-tubulin interactions.
    Arch Biochem Biophys. 1977 Jul;182(1):147-54 PMID: 883828
  16. Altered drug permeability in mammalian cell mutants.
    Adv Exp Med Biol. 1977;84:247-64 PMID: 899949
  17. Changes of activity of daunorubicin, adriamycin and stereoisomers following the introduction or removal of hydroxyl groups in the amino sugar moiety.
    Chem Biol Interact. 1977 Dec;19(3):291-302 PMID: 597963
  18. Mechanism of action and mechanism of resistance to antineoplastic agents that bind to DNA.
    Antibiot Chemother (1971). 1978;23:216-27 PMID: 348080
  19. Mechanisms of resistance to daunorubicin in Ehrlich ascites tumor cells.
    Cancer Res. 1978 Jun;38(6):1785-91 PMID: 647687
  20. Enhancement of the antitumor activity of adriamycin by Tween 80.
    Tumori. 1978 Apr 30;64(2):115-29 PMID: 675847
  21. Nascent chicken ovalbumin contains the functional equivalent of a signal sequence.
    J Cell Biol. 1978 Nov;79(2 Pt 1):567-72 PMID: 569160
  22. Molecular structural effects involved in the interaction of anthracyclines with DNA.
    Chem Biol Interact. 1979 Feb;24(2):217-25 PMID: 428012
  23. Intracellular pH.
    Physiol Rev. 1981 Apr;61(2):296-434 PMID: 7012859
  24. A Fickian diffusion transport process with features of transport catalysis. Doxorubicin transport in human red blood cells.
    J Gen Physiol. 1981 Oct;78(4):349-64 PMID: 7288392
  25. Characteristics of doxorubicin transport in human red blood cells.
    Scand J Clin Lab Invest. 1981 Nov;41(7):633-9 PMID: 7339865
  26. Synthesis of adriamycin-coupled polyglutaraldehyde microspheres and evaluation of their cytostatic activity.
    Proc Natl Acad Sci U S A. 1982 Mar;79(6):2026-30 PMID: 6804952
  27. The anticancer agent adriamycin can be actively cytotoxic without entering cells.
    Science. 1982 Jul 16;217(4556):248-50 PMID: 7089561
  28. Molecular association between doxorubicin (adriamycin) and DNA-derived bases, nucleosides, nucleotides, other aromatic compounds, and proteins in aqueous solution.
    Mol Pharmacol. 1982 Jul;22(1):158-65 PMID: 7121447
  29. Cell surface-mediated cytotoxicity of polymer-bound Adriamycin against drug-resistant hepatocytes.
    Cancer Res. 1983 Jun;43(6):2741-8 PMID: 6850589
  30. Energy-dependent reduced drug binding as a mechanism of Vinca alkaloid resistance in human leukemic lymphoblasts.
    Mol Pharmacol. 1983 Nov;24(3):485-92 PMID: 6579344
  31. Novel mode of cytotoxicity obtained by coupling inactive anthracycline to a polymer.
    Biochem Pharmacol. 1984 Feb 15;33(4):605-8 PMID: 6422950
  32. Cellular pharmacology of Vinca alkaloid resistance and its circumvention.
    Adv Enzyme Regul. 1984;22:207-27 PMID: 6089511
  33. Cellular transport of anthracyclines by passive diffusion. Implications for drug resistance.
    Biochem Pharmacol. 1985 Mar 1;34(5):593-8 PMID: 3856430
  34. Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.
    Cancer Res. 1985 Jul;45(7):3002-7 PMID: 4005839
  35. Markedly altered membrane transport and intracellular binding of vincristine in multidrug-resistant Chinese hamster cells selected for resistance to vinca alkaloids.
    J Cell Physiol. 1986 Feb;126(2):266-74 PMID: 3944208
  36. Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient.
    Biochim Biophys Acta. 1986 May 9;857(1):123-6 PMID: 3964703
  37. Regulation of cell pH by Ca+2-mediated exocytotic insertion of H+-ATPases.
    J Cell Biol. 1986 May;102(5):1638-45 PMID: 2871030
  38. Intracellular pH regulation in epithelial cells.
    Annu Rev Physiol. 1986;48:377-88 PMID: 3010818
  39. Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.
    Cancer Res. 1986 Nov;46(11):5941-6 PMID: 3756931
  40. Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins.
    Cell. 1986 Nov 7;47(3):371-80 PMID: 3768958
  41. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.
    Cell. 1986 Nov 7;47(3):381-9 PMID: 2876781
  42. Isolation and expression of a complementary DNA that confers multidrug resistance.
    Nature. 1986 Oct 23-29;323(6090):728-31 PMID: 3022150
  43. Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance.
    Nature. 1986 Dec 4-10;324(6096):485-9 PMID: 2878368
  44. Chloroquine enhancement of anticancer drug cytotoxicity in multiple drug resistant human leukemic cells.
    Biochem Pharmacol. 1986 Dec 1;35(23):4303-10 PMID: 3466591
  45. Increase in nonspecific adsorptive endocytosis in anthracycline- and vinca alkaloid-resistant Ehrlich ascites tumor cell lines.
    J Natl Cancer Inst. 1987 Jan;78(1):171-9 PMID: 3467125
  46. The carboxy-terminal region of haemolysin 2001 is required for secretion of the toxin from Escherichia coli.
    Mol Gen Genet. 1986 Oct;205(1):127-33 PMID: 3025555
  47. Cross-resistance patterns and antigen expression in Vinca alkaloid- and other multiple drug-resistant human leukemic cell lines.
    Prog Clin Biol Res. 1986;223:3-10 PMID: 3468517
  48. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.
    Proc Natl Acad Sci U S A. 1987 May;84(9):3004-8 PMID: 3472246
  49. The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein.
    Nature. 1989 Aug 3;340(6232):400-4 PMID: 2569166
  50. The biochemistry of P-glycoprotein-mediated multidrug resistance.
    Annu Rev Biochem. 1989;58:137-71 PMID: 2570548
  51. Doxorubicin resistance in P388 leukemia--evidence for reduced drug influx.
    Int J Cancer. 1989 Sep 15;44(3):539-47 PMID: 2777417
  52. Unknotting the complexities of multidrug resistance: the involvement of DNA topoisomerases in drug action and resistance.
    J Natl Cancer Inst. 1989 Nov 15;81(22):1683-5 PMID: 2553990
  53. Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells.
    EMBO J. 1989 Dec 20;8(13):3973-84 PMID: 2686977
  54. Improved cellular accumulation is characteristic of anthracyclines which retain high activity in multidrug resistant cell lines, alone or in combination with verapamil or cyclosporin A.
    Biochem Pharmacol. 1989 Dec 15;38(24):4467-75 PMID: 2604747
  55. A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence.
    EMBO J. 1990 May;9(5):1503-10 PMID: 2328723
  56. Elementary aspects of acid-base permeation and pH regulation.
    Ann N Y Acad Sci. 1989;574:333-53 PMID: 2483876
  57. Tamoxifen-induced increase in the potential doubling time of MCF-7 xenografts as determined by bromodeoxyuridine labeling and flow cytometry.
    Cancer Res. 1993 Sep 15;53(18):4413-7 PMID: 8364937
  58. Modulatory effects on substrate specificity of independent mutations at the serine939/941 position in predicted transmembrane domain 11 of P-glycoproteins.
    Biochemistry. 1993 Sep 14;32(36):9492-9 PMID: 8103679
  59. DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.
    Cancer Metastasis Rev. 1993 Jun;12(2):83-101 PMID: 8375023
  60. Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein.
    Eur J Cancer. 1993;29A(3):408-15 PMID: 8398342
  61. Changes in intra- or extracellular pH do not mediate P-glycoprotein-dependent multidrug resistance.
    Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9735-8 PMID: 8105483
  62. Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells.
    Br J Cancer. 1993 Nov;68(5):898-908 PMID: 8105865
  63. Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein.
    J Biol Chem. 1993 Nov 15;268(32):24197-202 PMID: 7901214
  64. Characterization of four doxorubicin adapted human breast cancer cell lines with respect to chemotherapeutic drug sensitivity, drug resistance associated membrane proteins and glutathione transferases.
    Anticancer Res. 1993 Sep-Oct;13(5A):1425-30 PMID: 7902062
  65. Ultrastructural localization of daunomycin in multidrug-resistant cultured cells with modulation of the multidrug transporter.
    J Histochem Cytochem. 1993 Oct;41(10):1573-7 PMID: 7902372
  66. Intracellular pH and the control of multidrug resistance.
    Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1128-32 PMID: 8302842
  67. On the origin of cancer cells.
    Science. 1956 Feb 24;123(3191):309-14 PMID: 13298683
  68. The cell biology of multiple drug resistance.
    Biochem Pharmacol. 1987 Sep 15;36(18):2879-87 PMID: 2888464
  69. Intracellular pH of astrocytes increases rapidly with cortical stimulation.
    Am J Physiol. 1987 Oct;253(4 Pt 2):R666-70 PMID: 3116863
  70. Release of a chimeric protein into the medium from Escherichia coli using the C-terminal secretion signal of haemolysin.
    EMBO J. 1987 Sep;6(9):2835-41 PMID: 3119330
  71. Effect of endogenous glutathione, superoxide dismutases, catalase, and glutathione peroxidase on adriamycin tolerance of Chinese hamster ovary cells.
    Cancer Res. 1988 Aug 15;48(16):4493-7 PMID: 3396001
  72. Reduced influx is a factor in accounting for reduced vincristine accumulation in certain verapamil-hypersensitive multidrug-resistant CHO cell lines.
    FEBS Lett. 1993 Apr 5;320(2):87-91 PMID: 8458436
  73. Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA.
    Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3231-5 PMID: 8386368
  74. Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site.
    Biochemistry. 1993 Apr 27;32(16):4185-94 PMID: 7682843
  75. Characteristics of the glutathione/glutathione-S-transferase detoxification system in melphalan resistant human prostate cancer cells.
    J Urol. 1993 Jul;150(1):209-14 PMID: 8510259
  76. Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines.
    Br J Cancer. 1993 Jun;67(6):1316-23 PMID: 8099807
  77. Preliminary studies about novel strategies to reverse chemoresistance to adriamycin regarding glutathione metabolism, peroxisomal and extraperoxisomal hydroperoxide and valproic acid metabolic pathways.
    Biol Cell. 1993;77(1):17-26 PMID: 8100159
  78. Localization of a novel multidrug resistance-associated gene in the HT1080/DR4 and H69AR human tumor cell lines.
    Cancer Res. 1993 Jul 15;53(14):3221-5 PMID: 8391919
  79. Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye.
    J Histochem Cytochem. 1990 May;38(5):685-90 PMID: 1692055
  80. What determines the substrate specificity of the multi-drug-resistance pump?
    Trends Biochem Sci. 1990 Feb;15(2):42-6 PMID: 1970910
  81. Characterization of liposomal systems containing doxorubicin entrapped in response to pH gradients.
    Biochim Biophys Acta. 1990 Jun 27;1025(2):143-51 PMID: 2364073
  82. Role of membrane lipids in the interaction of daunomycin with plasma membranes from tumor cells: implications in drug-resistance phenomena.
    Biochemistry. 1990 Aug 7;29(31):7275-82 PMID: 2207106
  83. Reversal of intrinsic multidrug resistance in Chinese hamster ovary cells by amiloride analogs.
    Br J Cancer. 1991 Feb;63(2):247-51 PMID: 1671752
  84. Secretion of lysosomal enzymes by drug-sensitive and multiple drug-resistant cells.
    Cancer Res. 1991 Apr 15;51(8):1996-2001 PMID: 1672622
  85. A protein-conducting channel in the endoplasmic reticulum.
    Cell. 1991 May 3;65(3):371-80 PMID: 1902142
  86. Mechanisms of multidrug resistance in human tumor cells. The roles of P-glycoprotein, DNA topoisomerase II, and other factors.
    Cancer Treat Rev. 1990 Dec;17 Suppl A:11-20 PMID: 1982639
  87. Decreased DNA topoisomerase II in daunorubicin-resistant Ehrlich ascites tumor cells.
    Cancer Res. 1991 Aug 15;51(16):4213-8 PMID: 1678312
  88. A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps.
    Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7289-93 PMID: 1678520
  89. Laser scanning and confocal microscopy of daunorubicin, doxorubicin, and rhodamine 123 in multidrug-resistant cells.
    Exp Cell Res. 1991 Oct;196(2):323-9 PMID: 1680064
  90. Modulation of ATP and drug binding by monoclonal antibodies against P-glycoprotein.
    J Cell Physiol. 1991 Sep;148(3):479-84 PMID: 1680871
  91. Fluorescent verapamil derivative for monitoring activity of the multidrug transporter.
    Mol Pharmacol. 1991 Oct;40(4):490-4 PMID: 1681415
  92. Energy-dependent processes involved in reduced drug accumulation in multidrug-resistant human lung cancer cell lines without P-glycoprotein expression.
    Cancer Res. 1992 Jan 1;52(1):17-23 PMID: 1309222
  93. The gene encoding vacuolar H(+)-ATPase subunit C is overexpressed in multidrug-resistant HL60 cells.
    Biochem Biophys Res Commun. 1992 Jan 31;182(2):675-81 PMID: 1370888
  94. Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein.
    Nature. 1992 Feb 27;355(6363):830-3 PMID: 1371598
  95. Reversal of Vinca alkaloid resistance by anti-P-glycoprotein monoclonal antibody HYB-241 in a human tumor xenograft.
    Cancer Res. 1992 Apr 1;52(7):1810-6 PMID: 1348013
  96. Peptide transport by the multidrug resistance pump.
    J Biol Chem. 1992 Mar 25;267(9):5731-4 PMID: 1348245
  97. Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene.
    Science. 1992 Apr 10;256(5054):232-4 PMID: 1348873
  98. What drives the translocation of proteins?
    Proc Natl Acad Sci U S A. 1992 May 1;89(9):3770-4 PMID: 1349170
  99. Transmembrane electrical potential difference regulates Na+/HCO3- cotransport and intracellular pH in hepatocytes.
    Proc Natl Acad Sci U S A. 1992 May 1;89(9):4197-201 PMID: 1570347
  100. Is the multidrug transporter a flippase?
    Trends Biochem Sci. 1992 Jan;17(1):18-21 PMID: 1374941
  101. Signal peptides open protein-conducting channels in E. coli.
    Cell. 1992 May 15;69(4):677-84 PMID: 1375130
  102. Mechanisms of multidrug resistance in cancer treatment.
    Acta Oncol. 1992;31(2):205-13 PMID: 1352455
  103. Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody.
    Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5824-8 PMID: 1352877
  104. Over-expression of P-glycoprotein and glutathione S-transferase pi in MCF-7 cells selected for vincristine resistance in vitro.
    Int J Cancer. 1992 Sep 9;52(2):241-6 PMID: 1355756
  105. Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.
    Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8472-6 PMID: 1356264
  106. Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein.
    Cell. 1992 Oct 2;71(1):23-32 PMID: 1382860
  107. Modulation of subcellular distribution of doxorubicin in multidrug-resistant P388/ADR mouse leukemia cells by the chemosensitizer ((2-isopropyl-1-(4-[3-N-methyl-N-(3,4-dimethoxy-beta- phenethyl)amino]propyloxy)-benzenesulfonyl))indolizine.
    Cancer Res. 1992 Dec 1;52(23):6440-6 PMID: 1423291
  108. The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.
    EMBO J. 1992 Dec;11(12):4291-303 PMID: 1385112
  109. Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway.
    J Biol Chem. 1992 Dec 5;267(34):24161-4 PMID: 1332947
  110. Quantification by laser scan microscopy of intracellular doxorubicin distribution.
    Cytometry. 1992;13(6):571-6 PMID: 1451589
  111. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.
    Science. 1992 Dec 4;258(5088):1650-4 PMID: 1360704
  112. Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.
    J Biol Chem. 1993 Jan 5;268(1):658-64 PMID: 8093247
  113. Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug-resistant cells expressing different levels of P-glycoprotein.
    Biochemistry. 1992 Dec 22;31(50):12555-64 PMID: 1361758
  114. The multidrug resistance (mdr1) gene product functions as an ATP channel.
    Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):312-6 PMID: 7678345
  115. Topology of P-glycoprotein as determined by epitope mapping of MRK-16 monoclonal antibody.
    J Biol Chem. 1993 Jan 25;268(3):1792-8 PMID: 7678410
  116. Volume-activated chloride channels in HeLa cells are blocked by verapamil and dideoxyforskolin.
    Pflugers Arch. 1993 Jan;422(4):347-53 PMID: 7679791
  117. The effects of lipids and detergents on ATPase-active P-glycoprotein.
    Biochim Biophys Acta. 1993 Feb 23;1146(1):65-72 PMID: 8095161
  118. Lack of reversal of daunorubicin resistance in HL60/AR cells by cyclosporin A.
    Anticancer Res. 1992 Nov-Dec;12(6B):2127-32 PMID: 1363515
  119. Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.
    Cancer Res. 1993 Apr 1;53(7):1475-9 PMID: 7680954
  120. Pentose phosphate pathway alterations in multi-drug resistant leukemic T-cells: 31P NMR and enzymatic studies.
    Anticancer Res. 1993 Jul-Aug;13(4):867-72 PMID: 8102518
  121. Biochemistry of multidrug resistance mediated by the multidrug transporter.
    Annu Rev Biochem. 1993;62:385-427 PMID: 8102521
  122. Reversal of doxorubicin-resistance in sarcoma 180 tumor cells by inhibition of different resistance mechanisms.
    Cancer Lett. 1993 Jul 16;70(3):197-202 PMID: 8102593
  123. Inwardly rectifying K+ channels and volume-regulated anion channels in multidrug-resistant small cell lung cancer cells.
    Cancer Res. 1993 Sep 15;53(18):4156-60 PMID: 8395978
  124. ON PHYSICO-CHEMICAL INTERACTIONS BETWEEN DAUNOMYCIN AND NUCLEIC ACIDS.
    Biochim Biophys Acta. 1965 May 11;103:25-49 PMID: 14336441
  125. Therapeutic attack of hypoxic cells of solid tumors: presidential address.
    Cancer Res. 1988 Feb 15;48(4):775-8 PMID: 3123053
  126. Increased plasma membrane traffic in daunorubicin resistant P388 leukaemic cells. Effect of daunorubicin and verapamil.
    Br J Cancer. 1987 Dec;56(6):747-51 PMID: 3435701
  127. Altered plasma membrane ultrastructure in multidrug-resistant cells.
    Biochim Biophys Acta. 1988 Feb 18;938(2):315-21 PMID: 2893642
  128. Cell and environment interactions in tumor microregions: the multicell spheroid model.
    Science. 1988 Apr 8;240(4849):177-84 PMID: 2451290
  129. Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.
    Mol Pharmacol. 1988 Apr;33(4):454-62 PMID: 3162758
  130. ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.
    Proc Natl Acad Sci U S A. 1988 May;85(10):3580-4 PMID: 3368466
  131. Selectivity of the anthracyclines for negatively charged model membranes: role of the amino group.
    Cancer Chemother Pharmacol. 1988;21(4):274-80 PMID: 3370735
  132. Inhibiting effect of the new cytotoxic antibiotic daunomycin on nucleic acids and mitotic activity of HeLa cells.
    J Cell Biol. 1965 Dec;27(3):545-50 PMID: 5885429
  133. Aggregation of microtubule subunit protein. Effects of divalent cations, colchicine and vinblastine.
    Biochemistry. 1970 Oct 13;9(21):4110-6 PMID: 5458644
  134. Interaction of daunomycin and its derivatives with DNA.
    Biochim Biophys Acta. 1972 Sep 14;277(3):489-98 PMID: 4672222
  135. Complex formation of daunomycin with double-stranded RNA.
    FEBS Lett. 1973 Nov 15;37(1):55-8 PMID: 4585033
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.9.3497
Published
1994-04-26
Pages
3497-504
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC43607
Subset
IM
Grants
NIGMS NIH HHS · R01 GM 47005 · United States
External Links
PubMed source DOI: 10.1073/pnas.91.9.3497 PMC Full Text View journal details
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