Modulation of RNA polymerase specificity by ppGpp.

Molecular & general genetics : MGG ·Vol. 147 ·No. 2 ·1976-08-19 ·Pages 225-32

Travers A

Abstract

ppGpp alters the initiation specificity of RNA polymerase holoenzyme in vitro in a direction which mimics the stringent response in vivo. The transition temperature for opening rRNA promoters is increased by the nucleotide, that for opening phi80 promoters is unaffected. This implies that RNA polymerase can discriminate between different types of promoter. ppGpp may act by effecting a structural change in the enzyme.

MeSH Terms

Coliphages/metabolism DNA, Viral Escherichia coli/enzymology Guanine Nucleotides/metabolism RNA, Bacterial RNA, Ribosomal/biosynthesis RNA, Viral Transcription, Genetic

Chemicals

DNA, Viral Guanine Nucleotides RNA, Bacterial RNA, Ribosomal RNA, Viral

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Travers A

References (15)

15 references, click to expand

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Article Info

Journal

Molecular & general genetics : MGG

Abbr.

Mol Gen Genet

ISSN

0026-8925

DOI

10.1007/BF00267575

Published

1976-08-19

Pages

225-32

Language

English

Region

Germany

NLM ID

0125036

Subset

External Links

PubMed source DOI: 10.1007/BF00267575

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Modulation of RNA polymerase specificity by ppGpp.

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