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PMID: 7870988 Published · ppublish English Journal Article

Contrasting effects of the competitive NMDA antagonist CPP and the non-competitive NMDA antagonist MK 801 on performance of an operant delayed matching to position task in rats.

Psychopharmacology ·Vol. 111 ·No. 4 ·1993-00-00 ·Pages 465-71

Cole BJ, Klewer M, Jones GH, Stephens DN

Abstract

The effects of the competitive NMDA antagonist CPP and the non-competitive NMDA antagonist MK 801 (dizolcipine) on short term working memory in the rat were investigated. The behavioural paradigm used was discrete trial, operant delayed matching to position, as originally described by Dunnett (1985), with delays of 0, 5, 15 and 30 s. These delays generated an orderly "forgetting" curve in control rats, with matching accuracy decreasing from approximately 100% at 0-s delay to approximately 75% at 30-s delay. Intraperitoneal (IP) administration of CPP (10 mg/kg) produced a marked delay dependent impairment in performance, suggesting a specific effect on short term working memory. This effect was accompanied by a minor decrease in the speed of responding, and a slight increase in the number of missed trials. Lower doses of CPP had no significant effects on either matching accuracy or sedation. In contrast, IP administration of MK 801 (0.1 and 0.2 mg/kg) caused a marked delay independent impairment in the accuracy of delayed matching performance, suggesting a non-specific disruption of performance. A lower dose (0.05 mg/kg) of MK 801 had no significant effect on matching accuracy. The two lower doses of MK 801 increased the number of nose pokes made during the delays and tended to increase the speed of responding, suggesting a stimulant-like action. The highest dose of MK 801 had the opposite effects and also decreased the number of trials completed.(ABSTRACT TRUNCATED AT 250 WORDS)

MeSH Terms
Animals Conditioning, Operant/drug effects Discrimination, Psychological/drug effects Dizocilpine Maleate/pharmacology Dose-Response Relationship, Drug Male Memory, Short-Term/drug effects Mental Recall/drug effects Piperazines/pharmacology Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors
Chemicals
Piperazines Receptors, N-Methyl-D-Aspartate Dizocilpine Maleate 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Cole B J
Department of Neuropsychopharmacology, Schering AG, Berlin, Germany.
Klewer M
Jones G H
Stephens D N
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF02253537
Published
1993-00-00
Pages
465-71
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02253537 View journal details
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