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PMID: 6115343 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones.

Neuroscience letters ·Vol. 23 ·No. 3 ·1981-05-29 ·Pages 333-6

Perkins MN, Stone TW, Collins JF, Curry K

Abstract

Phosphonate analogues of carboxylic acids have been tested as antagonists of excitatory aminoacids in rat cerebral cortex. (+/-)--2-Amino-7-phosphono-heptanoic acid and the (-)-D-isomer of the pentanoate derivative were more potent and selective antagonists of N-methyl-D-aspartate (NMDA) than compounds tested previously. The results support the view that a distinct population of receptors exists which are preferentially activated by NMDA.

MeSH Terms

2-Amino-5-phosphonovalerate Animals Aspartic Acid/analogs & derivatives,pharmacology Cerebral Cortex/drug effects,physiology Drug Antagonism Electric Conductivity Glutamates/pharmacology Glutamic Acid Isomerism Kainic Acid/pharmacology N-Methylaspartate Neurons/drug effects,physiology Organophosphorus Compounds/pharmacology Rats Valine/analogs & derivatives,pharmacology

Chemicals

Glutamates Organophosphorus Compounds Aspartic Acid Glutamic Acid N-Methylaspartate 2-Amino-5-phosphonovalerate Valine 2-amino-7-phosphonoheptanoic acid Kainic Acid

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Perkins M N

Stone T W

Collins J F

Curry K

Article Info

Journal

Neuroscience letters

Abbr.

Neurosci Lett

ISSN

0304-3940

DOI

10.1016/0304-3940(81)90021-5

Published

1981-05-29

Pages

333-6

Language

English

Region

Ireland

NLM ID

7600130

Subset

External Links

PubMed source DOI: 10.1016/0304-3940(81)90021-5 View journal details

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Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones.

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