Home LiteratureArticle Details
PMID: 785767 Published · ppublish English Journal Article Review

The Gordon Wilson lecture: function of blood platelets and their role in thrombosis.

Transactions of the American Clinical and Climatological Association ·Vol. 87 ·1976-00-00 ·Pages 104-27

Mustard JF

Abstract

The role of platelets in thrombosis has been reviewed. The possible relationship between platelets and thrombosis, vessel injury and the development of atherosclerosis is discussed. The implications of our understanding of platelets in thrombosis and clinical complications of arterial disease is reviewed together with possible value if drugs which modify platelet function.

MeSH Terms
Arteriosclerosis/complications,etiology,physiopathology Blood Coagulation Blood Platelets/drug effects,physiology Blood Vessels/pathology Embolism/etiology Endothelium/pathology Humans Myocardial Infarction/etiology Thrombosis/drug therapy,etiology,physiopathology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Mustard J F
References (74)
74 references, click to expand
  1. Encrustation and atherosclerosis: the analogy between early in vivo lesions and deposits which occur in extracorporeal circulations.
    Can Med Assoc J. 1962 Aug 11;87:259-74 PMID: 14477412
  2. Coagulation tests and platelet economy in atherosclerotic and control subjects.
    Circulation. 1962 Jan;25:114-25 PMID: 14477410
  3. The effect of hypercholesterolemia upon intimal repari of the aorta of the rabbit following experimental trauma.
    Am J Pathol. 1956 May-Jun;32(3):417-31 PMID: 13313713
  4. THE RELATION OF SUPERFICIAL CORTICAL SCARS OF THE KIDNEY TO AORTIC ATHEROSCLEROSIS; A HYPOTHESIS OF RENAL ISCHAEMIA.
    J Pathol Bacteriol. 1964 Oct;88:471-8 PMID: 14226419
  5. A PERMEABILITY FACTOR RELEASED FROM LEUKOCYTES AFTER PHAGOCYTOSIS OF IMMUNE COMPLEXES AND ITS POSSIBLE ROLE IN THE ARTHUS REACTION.
    Life Sci. 1964 Sep;3:1025-32 PMID: 14206043
  6. MURAL THROMBOSIS OF THE INTERNAL CAROTID ARTERY AND SUBSEQUENT EMBOLISM.
    Q J Med. 1964 Jan;33:155-95 PMID: 14116853
  7. RELEASE OF A PLATELET-AGGREGATING SUBSTANCE (ADENOSINE DIPHOSPHATE) FROM RABBIT BLOOD PLATELETS INDUCED BY SALINE "EXTRACT" OF TENDONS.
    Thromb Diath Haemorrh. 1963 Jul 15;143:264-78 PMID: 14081250
  8. Atherosclerotic metamorphosis of autologous pulmonary thromboemboli in the rabbit.
    Am J Pathol. 1962 Apr;40:469-86 PMID: 13904301
  9. The role of smooth muscle cells in the fibrogenesis of arteriosclerosis.
    Am J Pathol. 1960 Oct;37:377-89 PMID: 13712348
  10. White thrombo-embolism and vascular fragility in the hamster cheek pouch after anticoagulants.
    Blood. 1953 Feb;8(2):140-52 PMID: 13018348
  11. The role of thrombosis in the etiology of atherosclerosis (a positive one) and in precipitating fatal ischemic heart disease (a negative one).
    Semin Thromb Hemost. 1976 Jan;2(3):123-35 PMID: 798272
  12. Pulmonary capillary thrombosis in experimental pneumococcal septicemia.
    Arch Pathol. 1968 Feb;85(2):149-61 PMID: 4169545
  13. Sudden death due to coronary atherosclerotic heart disease. Age, smoking habits, and recent thrombi.
    JAMA. 1969 Feb 17;207(7):1347-9 PMID: 5818328
  14. Deposition of formed elements of blood on the intima and signs of intimal injury in the aorta of rabbit, pig, and man.
    Lab Invest. 1972 Sep;27(3):341-50 PMID: 4115813
  15. Increased endothelial cell turnover in areas of in vivo Evans Blue uptake in the pig aorta.
    Atherosclerosis. 1973 May-Jun;17(3):401-17 PMID: 4123526
  16. Thromboatherosclerosis in normolipemic rabbits. A result of continued endothelial damage.
    Lab Invest. 1973 Nov;29(5):478-87 PMID: 4127635
  17. The natural history of platelet-rich mural thrombi in systemic arteries of hypercholesterolaemic monkeys: light- and electron-microscope observations.
    J Pathol. 1973 Jul;110(3):203-12 PMID: 4200657
  18. Editorial: Viruses and arteriosclerosis.
    Am Heart J. 1974 Apr;87(4):407-12 PMID: 4361469
  19. Arteriovenous-shunt thrombosis. Prevention by sulfinpyrazone.
    N Engl J Med. 1974 Feb 7;290(6):304-6 PMID: 4588285
  20. Survival after resuscitation from out-of-hospital ventricular fibrillation.
    Circulation. 1974 Dec;50(6):1231-5 PMID: 4430117
  21. Focal aortic injury caused by cannulation: increased plasma protein accumulation and thrombosis.
    Acta Pathol Microbiol Scand A. 1974 Sep;82(5):637-47 PMID: 4137672
  22. Carbon monoxide-induced atherosclerosis in primates. An electron-microscopic study on the coronary arteries of Macaca trus monkeys.
    Atherosclerosis. 1974 Sep-Oct;20(2):233-40 PMID: 4412311
  23. Resolution and organization of platelet-rich mural thrombi in carotid arteries of swine.
    Am J Pathol. 1967 Nov;51(5):681-719 PMID: 4168026
  24. The effect of adenine nucleotides on thrombus formation, platelet count, and blood coagulation.
    Exp Mol Pathol. 1966 Feb;5(1):43-60 PMID: 5929590
  25. Aspirin selectively inhibits prostaglandin production in human platelets.
    Nat New Biol. 1971 Jun 23;231(25):235-7 PMID: 5284361
  26. Incorporation of 125 I-labelled fibrinogen into coronary arterial thrombi in acute myocardial infarction in man.
    Lancet. 1973 Feb 24;1(7800):387-90 PMID: 4119704
  27. Characterization of human platelet vascular permeability-enhancing activity.
    J Clin Invest. 1972 Mar;51(3):549-56 PMID: 4110899
  28. Repeated endothelial injury and induction of atherosclerosis in normolipemic rabbits by human serum.
    Lab Invest. 1975 Mar;32(3):404-15 PMID: 1123916
  29. The role of blood and platelets in atherosclerosis and the complications of atherosclerosis.
    Thromb Diath Haemorrh. 1975 Jun 30;33(3):444-56 PMID: 1154306
  30. Inhibition of injury induced thromboatherosclerotic lesions by anti-platelet serum in rabbits.
    Thromb Haemost. 1976 Feb 29;35(1):70-81 PMID: 989195
  31. Human platelet collagenase.
    J Clin Invest. 1974 Jun;53(6):1647-54 PMID: 4364408
  32. Platelets as a source of fibroblast growth-promoting activity.
    Exp Cell Res. 1974 Aug;87(2):297-301 PMID: 4370268
  33. Platelet factor-3 availability and the platelet release reaction.
    J Lab Clin Med. 1974 Oct;84(4):474-82 PMID: 4370267
  34. Platelet-inhibiting drugs in the prevention of clinical thrombotic disease (first of three parts).
    N Engl J Med. 1975 Dec 4;293(23):1174-8 PMID: 1102977
  35. The subendothelium and thrombogenesis.
    Bull N Y Acad Med. 1972 Feb;48(2):289-301 PMID: 4333358
  36. Effect of repeated treatment of rabbit platelets with low concentrations of thrombin on their function, metabolism and survival.
    Br J Haematol. 1973 Nov;25(5):675-89 PMID: 4356665
  37. The subendothelial microfibril and platelet adhesion.
    Lab Invest. 1971 Mar;24(3):179-86 PMID: 4323779
  38. The arterial medial cell, smooth muscle or multifunctional mesenchyme?
    J Atheroscler Res. 1968 Mar-Apr;8(2):201-13 PMID: 4232958
  39. Homocystinemia. Vascular injury and arterial thrombosis.
    N Engl J Med. 1974 Sep 12;291(11):537-43 PMID: 4212055
  40. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro.
    Proc Natl Acad Sci U S A. 1974 Apr;71(4):1207-10 PMID: 4208546
  41. Platelet interaction with polymerizing fibrin.
    J Clin Invest. 1972 Mar;51(3):685-99 PMID: 4622107
  42. Experimental arteriosclerosis. I. Fibrous plaque formation in primates, an electron microscope study.
    J Exp Med. 1972 Oct 1;136(4):769-89 PMID: 4626850
  43. Blood flow and thrombosis.
    Thromb Diath Haemorrh. 1974 Sep 30;32(1):35-48 PMID: 4616424
  44. Platelet factor 4 (PF-4). A study on methodology and physiology.
    Scand J Haematol. 1974;12(1):51-9 PMID: 4598702
  45. Evidence for a monoclonal origin of human atherosclerotic plaques.
    Proc Natl Acad Sci U S A. 1973 Jun;70(6):1753-6 PMID: 4515934
  46. Resolution of experimental pulmonary emboli with heparin and streptokinase in different dosage regimens.
    J Clin Invest. 1974 Oct;54(4):782-91 PMID: 4430712
  47. Arterial and venous thromboembolism: kinetic characterization and evaluation of therapy.
    Thromb Diath Haemorrh. 1974 May 15;31(2):188-203 PMID: 4850635
  48. Mural platelet microthrombi and major acute lesions of main epicardial arteries in sudden coronary death.
    Atherosclerosis. 1974 May-Jun;19(3):529-41 PMID: 4828572
  49. Platelet survival in patients with rheumatic heart disease.
    N Engl J Med. 1974 Mar 7;290(10):537-9 PMID: 4811098
  50. Platelet survival in patients with substitute heart valves.
    N Engl J Med. 1974 Mar 7;290(10):534-7 PMID: 4811097
  51. Lipid composition and metabolism of thromboatherosclerotic lesions produced by continued endothelial damage in normal rabbits.
    Circ Res. 1974 Apr;34(4):467-76 PMID: 4826923
  52. Instantaneous and sudden deaths. Clinical and pathological differentiation in coronary artery disease.
    JAMA. 1973 Sep 10;225(11):1319-28 PMID: 4740656
  53. The role of blood flow in platelet adhesion, fibrin deposition, and formation of mural thrombi.
    Microvasc Res. 1973 Mar;5(2):167-79 PMID: 4694283
  54. Platelet-dependent generation of chemotactic activity in serum.
    J Exp Med. 1973 Jun 1;137(6):1419-30 PMID: 4709268
  55. Focal ( 3 H)cholesterol uptake in the pig aorta. 2. Distribution of ( 3 H)cholesterol across the aortic wall in areas of high and low uptake in vivo.
    Atherosclerosis. 1972 Nov-Dec;16(3):377-88 PMID: 4657745
  56. Platelet aggregates in intramyocardial vessels of patients dying suddenly and unexpectedly of coronary artery disease.
    Atherosclerosis. 1972 Mar-Apr;15(2):199-213 PMID: 4666123
  57. The role of platelets in the contact phase of blood coagulation.
    Br J Haematol. 1972 Feb;22(2):237-54 PMID: 5057944
  58. The frequency and significance of coronary arterial thrombi and other observations in fatal acute myocardial infarction: a study of 107 necropsy patients.
    Am J Med. 1972 Apr;52(4):425-43 PMID: 5017237
  59. Hypertension and renal ischemia.
    Geriatrics. 1969 Jan;24(1):81-90 PMID: 4973035
  60. Vascular lesions: possible pathogenetic basis of the generalized Shwartzman reaction.
    Science. 1970 Nov 27;170(3961):986-8 PMID: 4920033
  61. The localization of circulating immune complexes in experimental serum sickness. The role of vasoactive amines and hydrodynamic forces.
    J Exp Med. 1968 Jan 1;127(1):119-36 PMID: 4864670
  62. Platelet economy (platelet survival and turnover).
    Br J Haematol. 1966 Jan;12(1):1-24 PMID: 5324586
  63. Platelets, thrombosis and drugs.
    Drugs. 1975;9(1):19-76 PMID: 1092540
  64. Platelet heparin-neutralizing factor (platelet factor 4).
    Thromb Diath Haemorrh. 1975 Feb 28;33(1):66-72 PMID: 1091019
  65. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.
    Proc Natl Acad Sci U S A. 1975 Aug;72(8):2994-8 PMID: 1059088
  66. Fibrinogen uptake by thrombi: effect of thrombus age.
    J Nucl Med. 1975 May;16(5):370-3 PMID: 1194988
  67. Sudden death from coronary heart disease. Survival time, frequency of thrombi, and cigarette smoking.
    Chest. 1970 Aug;58(2):107-10 PMID: 5455289
  68. Kinetics of cellular proliferation in experimental atherosclerosis. Radioautography with grain counts in cholesterol-fed rabbits.
    Arch Pathol. 1970 Feb;89(2):173-83 PMID: 5410986
  69. Effect of streptokinase on hemostasis.
    Blood. 1968 Nov;32(5):726-37 PMID: 5693908
  70. Endothelial mitosis around aortic branches in normal guinea pigs.
    Nature. 1968 Oct 5;220(5162):78-9 PMID: 5677450
  71. The organisation and fate of autologous pulmonary emboli in hypercholesterolaemic rabbits.
    J Pathol Bacteriol. 1968 Jan;95(1):19-29 PMID: 5643449
  72. Platelet adherence to fibrin and collagen.
    J Lab Clin Med. 1968 Jan;71(1):29-40 PMID: 5635007
  73. Adenosine diphosphate-induced platelet aggregation and myocardial infarction in swine.
    Lab Invest. 1967 Dec;17(6):616-44 PMID: 6080853
  74. Localized protein accumulation in the wall of the aorta.
    Exp Mol Pathol. 1967 Oct;7(2):214-32 PMID: 6053652
Article Info
Journal
Transactions of the American Clinical and Climatological Association
Abbr.
Trans Am Clin Climatol Assoc
ISSN
0065-7778
Published
1976-00-00
Pages
104-27
Language
English
Region
United States
NLM ID
7507559
PMCID
PMC2441384
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com