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PMID: 7849585 Published · ppublish English Journal Article Review

Influenza virus neuraminidase: structure, antibodies, and inhibitors.

Protein science : a publication of the Protein Society ·Vol. 3 ·No. 10 ·1994-10-00 ·Pages 1687-96

Colman PM

Abstract

The determination of the 3-dimensional structure of the influenza virus neuraminidase in 1983 has served as a platform for understanding interactions between antibodies and protein antigens, for investigating antigenic variation in influenza viruses, and for devising new inhibitors of the enzyme. That work is reviewed here, together with more recent developments that have resulted in one of the inhibitors entering clinical trials as an anti-influenza virus drug.

MeSH Terms
Antibodies/immunology Antigens/chemistry,immunology Antiviral Agents/chemistry Binding Sites Binding Sites, Antibody Models, Molecular Molecular Structure Neuraminidase/antagonists & inhibitors,chemistry,immunology Orthomyxoviridae/enzymology
Chemicals
Antibodies Antigens Antiviral Agents Neuraminidase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Colman P M
Biomolecular Research Institute, Parkville, Victoria, Australia.
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46 references, click to expand
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Article Info
Journal
Protein science : a publication of the Protein Society
Abbr.
Protein Sci
ISSN
0961-8368
DOI
10.1002/pro.5560031007
Published
1994-10-00
Pages
1687-96
Language
English
Region
United States
NLM ID
9211750
PMCID
PMC2142611
Subset
IM
External Links
PubMed source DOI: 10.1002/pro.5560031007 PMC Full Text View journal details
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