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PMID: 8502295 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Rational design of potent sialidase-based inhibitors of influenza virus replication.

Nature ·Vol. 363 ·No. 6428 ·1993-06-03 ·Pages 418-23

von Itzstein M, Wu WY, Kok GB, Pegg MS, Dyason JC, Jin B, Van Phan T, Smythe ML, White HF, Oliver SW

Abstract

Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus in cell culture and in animal models. The results provide an example of the power of rational, computer-assisted drug design, as well as indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection.

MeSH Terms

Animals Antiviral Agents/chemistry,pharmacology Cell Line Computer-Aided Design Disease Models, Animal Drug Design Female Ferrets Guanidines Humans Influenza A virus/drug effects,physiology Influenza, Human/drug therapy Mice Models, Molecular Neuraminidase/antagonists & inhibitors Pyrans Sheep Sialic Acids/chemistry,pharmacology Viral Plaque Assay Virus Replication/drug effects Zanamivir

Chemicals

Antiviral Agents Guanidines Pyrans Sialic Acids 4-amino-2-deoxy-2,3-didehydro-N-acetylneuraminic acid Neuraminidase Zanamivir

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

von Itzstein M

Department of Pharmaceutical Chemistry, Victorian College of Pharmacy, Monash University, Parkville, Australia.

Wu W Y

Kok G B

Pegg M S

Dyason J C

Jin B

Van Phan T

Smythe M L

White H F

Oliver S W

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/363418a0

Published

1993-06-03

Pages

418-23

Language

English

Region

England

NLM ID

0410462

Subset

Corrections

CommentIn

PMID: 8502294

External Links

PubMed source DOI: 10.1038/363418a0 View journal details

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Rational design of potent sialidase-based inhibitors of influenza virus replication.

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