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PMID: 7847882 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Nitrogen regulation in fungi.

Antonie van Leeuwenhoek ·Vol. 65 ·No. 3 ·1994-00-00 ·Pages 169-77

Caddick MX, Peters D, Platt A

Abstract

Nitrogen regulation has been extensively studied in fungi revealing a complex array of interacting regulatory genes. The general characterisation of the systems in Aspergillus nidulans and Neurospora crassa shall be briefly described, but much of this paper will concentrate specifically on the recent molecular characterisation of areA, the principle regulatory gene from A. nidulans which mediates nitrogen metabolite repression. Three areas shall be explored in detail, firstly the DNA binding domain, which has been characterised extensively by both molecular and genetic analysis. Secondly we shall report recent analysis which has revealed the presence of related DNA binding activities in A. nidulans. Finally we shall discuss the mechanism by which the nitrogen state of the cell is monitored by the areA product, in particular localisation of the domain within the areA product which mediates the regulatory response within the protein.

Related Genes
areA nit-2
MeSH Terms
Amino Acid Sequence Aspergillus nidulans/genetics,metabolism Binding Sites DNA, Fungal/metabolism DNA-Binding Proteins/genetics,metabolism Fungal Proteins/genetics,metabolism Fungi/genetics,metabolism Genes, Fungal Genes, Regulator Molecular Sequence Data Neurospora crassa/genetics,metabolism Nitrogen/metabolism Nitrogen Fixation/genetics Signal Transduction Transcription Factors/genetics,metabolism
Chemicals
AreA protein, Aspergillus nidulans DNA, Fungal DNA-Binding Proteins Fungal Proteins Transcription Factors Nitrogen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Caddick M X
Department of Genetics and Microbiology, Donnan Laboratories, University of Liverpool, UK.
Peters D
Platt A
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Article Info
Journal
Antonie van Leeuwenhoek
Abbr.
Antonie Van Leeuwenhoek
ISSN
0003-6072
DOI
10.1007/BF00871943
Published
1994-00-00
Pages
169-77
Language
English
Region
Netherlands
NLM ID
0372625
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00871943 View journal details
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