Home LiteratureArticle Details
PMID: 7815538 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Neutralizing antibodies in Borna disease virus-infected rats.

Journal of virology ·Vol. 69 ·No. 2 ·1995-02-00 ·Pages 741-7

Hatalski CG, Kliche S, Stitz L, Lipkin WI

Abstract

Borna disease is a neurologic syndrome caused by infection with a nonsegmented, negative-strand RNA virus, Borna disease virus. Infected animals have antibodies to two soluble viral proteins, p40 and p23, and a membrane-associated viral glycoprotein, gp18. We examined the time course for the development of neutralization activity and the expression of antibodies to individual viral proteins in sera of infected rats. The appearance of neutralizing activity correlated with the development of immunoreactivity to gp18, but not p40 or p23. Monospecific and monoclonal antibodies to native gp18 and recombinant nonglycosylated gp18 were also found to have neutralizing activity and to immunoprecipitate viral particles or subparticles. These findings suggest that gp18 is likely to be present on the surface of the viral particles and is likely to contain epitopes important for virus neutralization.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Antibodies, Viral/blood Borna Disease/immunology Borna disease virus/immunology Glycoproteins/immunology Immunization Rats Rats, Inbred Lew
Chemicals
Antibodies, Monoclonal Antibodies, Viral Glycoproteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hatalski C G
Department of Neurology, University of California, Irvine 92717.
Kliche S
Stitz L
Lipkin W I
References (50)
50 references, click to expand
  1. Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system.
    Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7252-6 PMID: 1496020
  2. Borna disease virus-specific antigens. II. The soluble antigen is a protein complex.
    Vet Immunol Immunopathol. 1992 Mar;31(3-4):361-9 PMID: 1375406
  3. Sequence similarity between Borna disease virus p40 and a duplicated domain within the paramyxovirus and rhabdovirus polymerase proteins.
    J Virol. 1992 Nov;66(11):6572-7 PMID: 1404604
  4. Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells.
    Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11486-9 PMID: 1454837
  5. Borna disease virus in mice: host-specific differences in disease expression.
    J Virol. 1993 Jan;67(1):548-52 PMID: 8416380
  6. Mechanisms of antibody-mediated protection against lymphocytic choriomeningitis virus infection: mother-to-baby transfer of humoral protection.
    J Virol. 1992 Jul;66(7):4252-7 PMID: 1376367
  7. Genomic organization of the structural proteins of borna disease virus revealed by a cDNA clone encoding the 38-kDa protein.
    Virology. 1993 Jul;195(1):229-38 PMID: 8317098
  8. Persistent, tolerant or subacute infection in Borna disease virus-infected rats.
    J Gen Virol. 1983 Jul;64 (Pt 7):1521-30 PMID: 6408221
  9. Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities.
    J Infect Dis. 1983 Aug;148(2):305-15 PMID: 6604114
  10. Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation.
    Science. 1984 Aug 17;225(4663):687-93 PMID: 6431612
  11. Focus-immunoassay for Borna disease virus-specific antigens.
    Zentralbl Veterinarmed B. 1984 Aug;31(7):552-7 PMID: 6207686
  12. Effect of Borna disease virus infection on athymic rats.
    J Gen Virol. 1985 Mar;66 ( Pt 3):503-8 PMID: 3919150
  13. Role of antibody in primary and recurrent herpes simplex virus infection.
    J Virol. 1985 Mar;53(3):944-8 PMID: 2983100
  14. Isolation and characterization of a 14500 molecular weight protein from brains and tissue cultures persistently infected with borna disease virus.
    J Gen Virol. 1985 Nov;66 ( Pt 11):2479-84 PMID: 3932595
  15. Purification and properties of an intranuclear virus-specific antigen from tissue infected with Borna disease virus.
    J Gen Virol. 1986 Feb;67 ( Pt 2):235-41 PMID: 3080548
  16. [Borna virus infection (Borna disease) in naturally and experimentally infected animals: its significance for research and practice].
    Tierarztl Prax. 1985;13(4):421-53 PMID: 3834641
  17. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
    Anal Biochem. 1987 Apr;162(1):156-9 PMID: 2440339
  18. Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation.
    J Virol. 1987 Nov;61(11):3431-40 PMID: 2444715
  19. Borna disease: a persistent virus infection of the central nervous system.
    Prog Med Virol. 1988;35:107-51 PMID: 3051132
  20. Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing).
    J Virol. 1988 Dec;62(12):4594-604 PMID: 2460637
  21. Survival of athymic (nu/nu) mice after Theiler's murine encephalomyelitis virus infection by passive administration of neutralizing monoclonal antibody.
    J Virol. 1989 May;63(5):2081-7 PMID: 2539504
  22. Neutralization of animal viruses.
    Curr Top Microbiol Immunol. 1993;183:1-149 PMID: 8354080
  23. Biology and neurobiology of Borna disease viruses (BDV), defined by antibodies, neutralizability and their pathogenic potential.
    Arch Virol Suppl. 1993;7:111-33 PMID: 8219797
  24. Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells.
    J Immunol. 1993 Nov 15;151(10):5408-15 PMID: 7693811
  25. Borna disease in ostriches.
    Vet Rec. 1993 Sep 18;133(12):304 PMID: 8204140
  26. Natural Borna disease in domestic animals others than horses and sheep.
    Zentralbl Veterinarmed B. 1993 Jun;40(4):298-303 PMID: 8237201
  27. Sequence conservation in field and experimental isolates of Borna disease virus.
    J Virol. 1994 Jan;68(1):63-8 PMID: 8254777
  28. Sequence and genome organization of Borna disease virus.
    J Virol. 1994 Mar;68(3):1382-96 PMID: 7906311
  29. Genomic organization of Borna disease virus.
    Proc Natl Acad Sci U S A. 1994 May 10;91(10):4362-6 PMID: 8183914
  30. N-glycosylated protein(s) are important for the infectivity of Borna disease virus (BDV).
    Arch Virol. 1994;137(3-4):405-9 PMID: 7944960
  31. Maturation of the head of bacteriophage T4. I. DNA packaging events.
    J Mol Biol. 1973 Nov 15;80(4):575-99 PMID: 4204102
  32. The cerebrospinal fluid of rabbits infected with Borna disease virus.
    Arch Virol. 1977;55(3):209-23 PMID: 597037
  33. Demonstration of specific antibodies in the central nervous system of horses naturally infected with Borna disease virus.
    Med Microbiol Immunol. 1977 Dec 27;163(4):215-26 PMID: 604728
  34. [Comparative studies on the demonstration and formation of serum antibodies against the Borna virus].
    Zentralbl Veterinarmed B. 1978 Jun;25(5):345-55 PMID: 358683
  35. A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines.
    J Immunol. 1979 Oct;123(4):1548-50 PMID: 113458
  36. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
    Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350-4 PMID: 388439
  37. Replication of Borna disease virus in cell cultures.
    Med Microbiol Immunol. 1980;168(3):153-8 PMID: 6772932
  38. Antibody-induced restriction of viral gene expression in measles encephalitis in rats.
    J Virol. 1990 Feb;64(2):706-13 PMID: 2296081
  39. Antibody inhibits defined stages in the pathogenesis of reovirus serotype 3 infection of the central nervous system.
    J Exp Med. 1989 Sep 1;170(3):887-900 PMID: 2549167
  40. Behavioral disease in rats caused by immunopathological responses to persistent borna virus in the brain.
    Science. 1983 Jun 24;220(4604):1401-3 PMID: 6602380
  41. Mechanisms of neutralization of influenza virus on mouse tracheal epithelial cells by mouse monoclonal polymeric IgA and polyclonal IgM directed against the viral haemagglutinin.
    J Gen Virol. 1990 Jan;71 ( Pt 1):69-76 PMID: 2303801
  42. Isolation and characterization of Borna disease agent cDNA clones.
    Proc Natl Acad Sci U S A. 1990 Jun;87(11):4184-8 PMID: 1693432
  43. Molecular characterization of the Borna disease agent.
    Virology. 1990 Dec;179(2):853-6 PMID: 2238474
  44. A borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases.
    Science. 1990 Nov 30;250(4985):1278-81 PMID: 2244211
  45. Analysis of Borna disease virus-specific RNAs in infected cells and tissues.
    J Gen Virol. 1991 Sep;72 ( Pt 9):2251-5 PMID: 1895063
  46. Antibody-mediated clearance of alphavirus infection from neurons.
    Science. 1991 Nov 8;254(5033):856-60 PMID: 1658936
  47. The 24K protein of Borna disease virus.
    J Gen Virol. 1992 Feb;73 ( Pt 2):413-6 PMID: 1538196
  48. Preventive effects of early anti-CD4 or anti-CD8 treatment on Borna disease in rats.
    J Virol. 1992 Jun;66(6):3316-23 PMID: 1374805
  49. Antigenic relationship and further characterization of two major Borna disease virus-specific proteins.
    J Gen Virol. 1992 May;73 ( Pt 5):1057-64 PMID: 1588316
  50. Identification of equine herpesvirus 4 glycoprotein G: a type-specific, secreted glycoprotein.
    Virology. 1992 Sep;190(1):143-54 PMID: 1529525
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.69.2.741-747.1995
Published
1995-02-00
Pages
741-7
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC188637
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.69.2.741-747.1995 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2