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PMID: 7815511 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Induction of protective cytotoxic T cells to murine cytomegalovirus by using a nonapeptide and a human-compatible adjuvant (Montanide ISA 720).

Journal of virology ·Vol. 69 ·No. 2 ·1995-02-00 ·Pages 1306-9

Scalzo AA, Elliott SL, Cox J, Gardner J, Moss DJ, Suhrbier A

Abstract

The use of synthetic peptides representing cytotoxic T-cell (CTL) epitopes for human vaccination requires the identification of a suitable adjuvant formulation. A single immunization with Montanide ISA720/tetanus toxoid/YPHFMPTNL protected mice against murine cytomegalovirus and induced epitope-specific CTL. Such formulations will find application in peptide-based CTL anti-viral vaccines.

MeSH Terms
Adjuvants, Immunologic/pharmacology Amino Acid Sequence Animals Antigens, Viral/immunology Humans Mice Mice, Inbred BALB C Molecular Sequence Data Muromegalovirus/immunology Oligopeptides/immunology T-Lymphocytes, Cytotoxic/immunology Tetanus Toxoid/immunology Vaccination Viral Vaccines/immunology
Chemicals
Adjuvants, Immunologic Antigens, Viral Oligopeptides Tetanus Toxoid Viral Vaccines
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Scalzo A A
Department of Microbiology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands.
Elliott S L
Cox J
Gardner J
Moss D J
Suhrbier A
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.69.2.1306-1309.1995
Published
1995-02-00
Pages
1306-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC188710
Subset
IM
Grants
NCI NIH HHS · CA 57952 · United States
External Links
PubMed source DOI: 10.1128/JVI.69.2.1306-1309.1995 PMC Full Text View journal details
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