Abstract
Haemophilus ducreyi can bind hemoglobin and use it as a source of heme, for which it has an obligate requirement. We previously identified and purified HgbA, a hemoglobin-binding outer membrane protein from H. ducreyi. In this report, we describe the molecular cloning, expression, DNA sequence, and mutagenesis of the structural gene for HgbA, hgbA. H. ducreyi and recombinant Escherichia coli expressing hgbA bound [125I]hemoglobin, establishing HgbA as a receptor. Insertions or deletions in the cloned hgbA gene abolished expression of HgbA and hemoglobin binding in E. coli. Mutagenesis of H. ducreyi by allelic exchange of insertions into hgbA abolished its ability to bind [125I]hemoglobin or utilize hemoglobin as a source of heme. The deduced protein sequence was similar to those of the TonB-dependent family of outer membrane receptors. The most similar member was HutA (heme receptor) from Vibrio cholerae. Tbp1 and Lbp1 (transferrin and lactoferrin receptors, respectively, from pathogenic Neisseria spp.) also showed very significant homology. Thus, by characterizing the hgbA locus, this work elucidates a potentially important role of HgbA in obtaining heme and/or iron from the host.
MeSH Terms
Amino Acid Sequence
Bacterial Outer Membrane Proteins/chemistry,genetics,physiology
Bacterial Proteins/genetics
Base Sequence
Carrier Proteins/chemistry,genetics,physiology
Chromosome Mapping
Cloning, Molecular
DNA, Bacterial/chemistry
Escherichia coli/genetics
Escherichia coli Proteins
Haemophilus ducreyi/genetics
Hemoglobins/metabolism
Membrane Proteins/genetics
Molecular Sequence Data
Mutation
Sequence Homology, Amino Acid
Chemicals
Bacterial Outer Membrane Proteins
Bacterial Proteins
Carrier Proteins
DNA, Bacterial
Escherichia coli Proteins
Hemoglobins
Membrane Proteins
hemoglobin-binding protein, bacteria
tonB protein, Bacteria
tonB protein, E coli
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Elkins C
Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill 27599, USA.
Chen C J
Thomas C E
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