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PMID: 7761389 Published · ppublish English Comment Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Mechanisms for the pleiotropic effects of the agouti gene.

Manne J, Argeson AC, Siracusa LD

Abstract

暂无摘要

MeSH Terms
Agouti Signaling Protein Amino Acid Sequence Animals Carnivora Hair Color/genetics Humans Intercellular Signaling Peptides and Proteins Mice Mice, Mutant Strains Mice, Transgenic Molecular Sequence Data Mollusk Venoms/chemistry Mutation Proteins/chemistry,genetics Rabbits Sciuridae Sequence Homology, Amino Acid
Chemicals
Agouti Signaling Protein Intercellular Signaling Peptides and Proteins Mollusk Venoms Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Manne J
Jefferson Cancer Institute, Thomas Jefferson University, Department of Microbiology and Immunology, Philadelphia, PA 19107, USA.
Argeson A C
Siracusa L D
References (41)
41 references, click to expand
  1. Diversity of Conus neuropeptides.
    Science. 1990 Jul 20;249(4966):257-63 PMID: 2165278
  2. Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.
    Proc Natl Acad Sci U S A. 1995 May 23;92(11):4728-32 PMID: 7761391
  3. Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators.
    J Natl Cancer Inst. 1994 Sep 7;86(17):1286-96 PMID: 8064887
  4. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.
    Genes Dev. 1993 Mar;7(3):454-67 PMID: 8449404
  5. The agouti gene: turned on to yellow.
    Trends Genet. 1994 Dec;10(12):423-8 PMID: 7871591
  6. Evidence for distinct sites coupled to high affinity omega-conotoxin receptors in rat brain synaptic plasma membrane vesicles.
    Biochem Biophys Res Commun. 1988 Jul 15;154(1):298-305 PMID: 2840068
  7. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor.
    Nature. 1994 Oct 27;371(6500):799-802 PMID: 7935841
  8. Nuclear calcium transport and the role of calcium in apoptosis.
    Cell Calcium. 1994 Oct;16(4):279-88 PMID: 7820847
  9. Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage.
    Genes Dev. 1994 Jun 15;8(12):1463-72 PMID: 7926745
  10. Neomorphic agouti mutations in obese yellow mice.
    Nat Genet. 1994 Sep;8(1):59-65 PMID: 7987393
  11. Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene.
    FASEB J. 1994 May;8(8):479-88 PMID: 8181666
  12. Isolation and sequencing of insecticidal peptides from the primitive hunting spider, Plectreurys tristis (Simon).
    J Biol Chem. 1994 Apr 15;269(15):11098-101 PMID: 8157635
  13. More to colour than meets the eye.
    Curr Biol. 1993 Aug 1;3(8):518-21 PMID: 15335692
  14. Cytosolic calcium and insulin resistance.
    Am J Kidney Dis. 1993 Jun;21(6 Suppl 3):32-8 PMID: 8503433
  15. Cytosolic free calcium in adipocytes. Distinct mechanisms of regulation and effects on insulin action.
    J Biol Chem. 1989 Aug 5;264(22):12754-7 PMID: 2666413
  16. New roles for G-protein beta gamma-dimers in transmembrane signalling.
    Nature. 1993 Sep 30;365(6445):403-6 PMID: 8413584
  17. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene.
    Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5667-71 PMID: 8202545
  18. Molecular structure and chromosomal mapping of the human homolog of the agouti gene.
    Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9760-4 PMID: 7937887
  19. Structure and function of ASP, the human homolog of the mouse agouti gene.
    Hum Mol Genet. 1995 Feb;4(2):223-30 PMID: 7757071
  20. Spider toxins selectively block calcium currents in Drosophila.
    Neuron. 1989 Dec;3(6):767-72 PMID: 2642017
  21. Calcium, calmodulin and cell cycle regulation.
    FEBS Lett. 1994 Jun 20;347(1):1-4 PMID: 8013652
  22. Diabetes mellitus: a disease of abnormal cellular calcium metabolism?
    Am J Med. 1994 Mar;96(3):260-73 PMID: 8154515
  23. Calcium signaling.
    Cell. 1995 Jan 27;80(2):259-68 PMID: 7834745
  24. Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins.
    Annu Rev Biochem. 1994;63:823-67 PMID: 7979255
  25. Constant and hypervariable regions in conotoxin propeptides.
    EMBO J. 1990 Apr;9(4):1015-20 PMID: 1691090
  26. Precursor structure of omega-conotoxin GVIA determined from a cDNA clone.
    Toxicon. 1992 Sep;30(9):1111-6 PMID: 1440648
  27. Calcium-mediated signal transduction: biology, biochemistry, and therapy.
    Cancer Metastasis Rev. 1994 Mar;13(1):31-44 PMID: 8143344
  28. Molecular and cellular physiology of intracellular calcium stores.
    Physiol Rev. 1994 Jul;74(3):595-636 PMID: 8036248
  29. The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein.
    Genes Dev. 1993 Jul;7(7A):1203-13 PMID: 8319910
  30. Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts.
    Genes Dev. 1994 Feb 15;8(4):481-90 PMID: 8125260
  31. Conotoxins.
    J Biol Chem. 1991 Nov 25;266(33):22067-70 PMID: 1939227
  32. Ionic basis of hypertension, insulin resistance, vascular disease, and related disorders. The mechanism of "syndrome X".
    Am J Hypertens. 1993 Apr;6(4):123S-134S PMID: 8507440
  33. Evidence of mammalian Ca2+ channel inhibitors in venom of the spider Plectreurys tristis.
    Toxicon. 1993 Oct;31(10):1249-56 PMID: 8303719
  34. Molecular characterization of the mouse agouti locus.
    Cell. 1992 Dec 24;71(7):1195-204 PMID: 1473152
  35. Biochemical mechanisms of insulin resistance.
    Horm Res. 1994;41 Suppl 2:51-5 PMID: 8088704
  36. Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila.
    J Neurosci. 1987 Dec;7(12):4195-200 PMID: 2826721
  37. Calcium channels, stores, and oscillations.
    Annu Rev Cell Biol. 1990;6:715-60 PMID: 2177344
  38. Inositol trisphosphate and calcium signalling.
    Nature. 1993 Jan 28;361(6410):315-25 PMID: 8381210
  39. Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice.
    Proc Natl Acad Sci U S A. 1995 May 23;92(11):4733-7 PMID: 7761392
  40. Pleiotropic effects of the mouse lethal yellow (Ay) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs.
    Development. 1994 Jun;120(6):1695-708 PMID: 8050375
  41. A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation.
    Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2562-6 PMID: 8146154
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
1995-05-23
Pages
4721-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC41778
Subset
IM
Grants
NCI NIH HHS · 5T32CA09678 · United States
Corrections
CommentOn
CommentOn
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