Home LiteratureArticle Details
PMID: 773728 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

High concentration of somatostatin immunoreactivity in chicken pancreas.

Diabetologia ·Vol. 12 ·No. 2 ·1976-05-00 ·Pages 129-32

Weir GC, Goltsos PC, Steinberg EP, Patel YC

Abstract

Extracts of discrete lobes of chicken pancreas were assayed for somatostatin (SRIF), insulin and glucagon immunoreactivity. The distribution of hormone concentration was correlated appropriately with the known distribution of A, B, and D-cells. Concentrations of all three hormones were highest in the splenic lobe. The glucagon content of the ventral and dorsal lobes was low. Evidence is presented that the SRIF-like material in the pancreatic extracts is very similar to synthetic cyclic SRIF; parallel immunoassay displacement curves and similar chromatographic elution profiles were obtained. The SRIF concentration in chicken pancreas is 21 times higher than that found in the rat. Chicken pancreas may provide a useful model for studies of somatostatin physiology.

MeSH Terms
Animals Chickens Glucagon/analysis Insulin/analysis Islets of Langerhans/analysis Radioimmunoassay Somatostatin/analysis
Chemicals
Insulin Somatostatin Glucagon
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Weir G C
Goltsos P C
Steinberg E P
Patel Y C
References (20)
20 references, click to expand
  1. [Inhibition by somatostatin of pancreatic juice and enzyme secretion and gallbladder contraction in man induced by secretin and cholecystokinin-pancreozymin administration (author's transl)].
    Dtsch Med Wochenschr. 1975 May 16;100(20):1135-8 PMID: 1126301
  2. Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas.
    Proc Natl Acad Sci U S A. 1975 Apr;72(4):1340-3 PMID: 1093177
  3. Growth-hormone release-inhibiting hormone in gastrointestinal and pancreatic D cells.
    Lancet. 1975 May 31;1(7918):1220-2 PMID: 48838
  4. Insulin and glucose as modulators of the amino acid-induced glucagon release in the isolated pancreas of alloxan and streptozotocin diabetic rats.
    J Clin Invest. 1975 Feb;55(2):244-55 PMID: 123928
  5. D cell, the third endocrine element of the pancreatic islet.
    Arch Histol Jpn. 1968 Feb;29(1):1-40 PMID: 4172729
  6. Somatostatin: hypothalamic inhibitor of the endocrine pancreas.
    Science. 1974 Apr 26;184(4135):482-4 PMID: 4594711
  7. Inhibition by somatostatin of ACTH secretion in Nelson's syndrome.
    J Clin Endocrinol Metab. 1975 Jun;40(6):1125-7 PMID: 166089
  8. [Effect of somatostatin on betazole-stimulated gastric secretion and carbachol-stimulated pancreatic secretion and gall bladder contraction in man(author's transl)].
    Dtsch Med Wochenschr. 1975 Sep 5;100(36):1797-800 PMID: 1157680
  9. Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone.
    Lancet. 1974 Nov 9;2(7889):1106-9 PMID: 4139406
  10. Studies of the distribution of a new avian pancreatic polypeptide and insulin among birds, reptiles, amphibians and mammals.
    Endocrinology. 1973 Sep;93(3):558-65 PMID: 4198471
  11. Radioimmunoassay for GH-release inhibiting hormone.
    Proc Soc Exp Biol Med. 1975 Mar;148(3):784-9 PMID: 1129301
  12. Somatostatin suppresses secretin and pancreatic exocrine secretion.
    Science. 1975 Oct 10;190(4210):163-5 PMID: 1166308
  13. Somatostatin: abundance of immunoreactive hormone in rat stomach and pancreas.
    Science. 1975 Sep 19;189(4207):1007-9 PMID: 56779
  14. Effects of somatostatin on the secretion of thyrotropin and prolactin.
    Endocrinology. 1974 Oct;95(4):968-77 PMID: 4213073
  15. Glucagon secretion from the perfused rat pancreas. Studies with glucose and catecholamines.
    J Clin Invest. 1974 Dec;54(6):1403-12 PMID: 4373494
  16. A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties.
    Acta Endocrinol (Copenh). 1972 Jul;70(3):487-509 PMID: 5068062
  17. Inhibition of growth hormone release in humans by somatostatin.
    J Clin Endocrinol Metab. 1973 Oct;37(4):632-4 PMID: 4742541
  18. Evidence for the D-cell of the pancreas secreting somatostatin.
    Horm Metab Res. 1975 Sep;7(5):400-2 PMID: 1102409
  19. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.
    Science. 1973 Jan 5;179(4068):77-9 PMID: 4682131
  20. Glucagon deficiency induced by extirpation of alpha islets of the fowl pancreas.
    Endocrinology. 1962 Sep;71:464-73 PMID: 14473676
Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00428977
Published
1976-05-00
Pages
129-32
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00428977 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2