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PMID: 7707551 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Bovine papillomavirus E1 protein can, by itself, efficiently drive multiple rounds of DNA synthesis in vitro.

Journal of virology ·Vol. 69 ·No. 5 ·1995-05-00 ·Pages 3201-5

Bonne-Andrea C, Santucci S, Clertant P

Abstract

Bovine papillomavirus E1 protein was found to be as efficient as the simian virus 40 large T antigen in initiating DNA synthesis in a cell-free system derived from COS1 cells. Multiple rounds of DNA synthesis occur, initiated at the bovine papillomavirus type 1 origin. Therefore, E1 functions in vitro as a lytic virus initiator.

MeSH Terms
Animals Antigens, Polyomavirus Transforming/metabolism Bovine papillomavirus 1/genetics,metabolism,physiology Cattle Cell Line DNA Replication/genetics DNA, Viral/biosynthesis DNA-Binding Proteins/metabolism In Vitro Techniques Replication Origin Simian virus 40/metabolism Viral Proteins/metabolism Virus Replication
Chemicals
Antigens, Polyomavirus Transforming DNA, Viral DNA-Binding Proteins E1 protein, Bovine papillomavirus Viral Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bonne-Andrea C
Centre de Biochimie, Unité 273 de l'Institut National de la Santé et de la Recherche Médicale, Nice, France.
Santucci S
Clertant P
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.69.5.3201-3205.1995
Published
1995-05-00
Pages
3201-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC189025
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.69.5.3201-3205.1995 PMC Full Text View journal details
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