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PMID: 7678101 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Staphylococcal enterotoxin A gene (sea) expression is not affected by the accessory gene regulator (agr).

Infection and immunity ·Vol. 61 ·No. 1 ·1993-01-00 ·Pages 356-9

Tremaine MT, Brockman DK, Betley MJ

Abstract

The goal of this work was to determine whether staphylococcal enterotoxin type A gene (sea) expression is regulated by an accessory gene regulator (agr). The Tn551 insertionally inactivated agr allele of Staphylococcus aureus ISP546 was transferred to three Sea+ S. aureus strains. Each of the Agr- strains produced as much staphylococcal enterotoxin A (SEA) as its parent strain. These results suggest that sea expression is regulated differently from that of seb, sec, and sed, which previously have been shown to require a functional agr system for maximal expression.

Related Genes
agr sea seb sec sed
MeSH Terms
Blotting, Northern Blotting, Western Enterotoxins/biosynthesis Gene Expression Regulation, Bacterial/physiology Genes, Bacterial/physiology Genes, Regulator/physiology Interferon Inducers RNA/biosynthesis Staphylococcus aureus/metabolism
Chemicals
Enterotoxins Interferon Inducers enterotoxin A, Staphylococcal enterotoxin B, staphylococcal RNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tremaine M T
University of Wisconsin-Madison 53706.
Brockman D K
Betley M J
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24 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.61.1.356-359.1993
Published
1993-01-00
Pages
356-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC302730
Subset
IM
Grants
NIAID NIH HHS · AI25574 · United States
External Links
PubMed source DOI: 10.1128/iai.61.1.356-359.1993 PMC Full Text View journal details
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