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PMID: 7643969 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation.

Neurochemical research ·Vol. 20 ·No. 5 ·1995-05-00 ·Pages 631-6

Mohler H, Knoflach F, Paysan J, Motejlek K, Benke D, Lüscher B, Fritschy JM

Abstract

Vigilance, anxiety, memory, epileptogenic activity and muscle tension can be regulated by a modulation of GABAA-receptor function. A multitude of different GABAA-receptors exist in the brain due to the combinational assembly of various subunits encoded by at least 15 genes. The clarification of the physiological and pharmacological significance of GABAA-receptor subtypes, in combination with their cellular localization, will make it possible to identify the neuronal circuits regulating the respective CNS states and to provide strategies for the development of subtype-specific drugs for selective therapies.

MeSH Terms
Animals Brain/cytology,metabolism Gene Expression Regulation/physiology Immunohistochemistry Neurons/chemistry Receptors, GABA-A/analysis,chemistry,drug effects
Chemicals
Receptors, GABA-A
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Mohler H
Institute of Pharmacology, University, Zürich, Switzerland.
Knoflach F
Paysan J
Motejlek K
Benke D
Lüscher B
Fritschy J M
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Article Info
Journal
Neurochemical research
Abbr.
Neurochem Res
ISSN
0364-3190
DOI
10.1007/BF01694546
Published
1995-05-00
Pages
631-6
Language
English
Region
United States
NLM ID
7613461
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01694546 View journal details
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