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PMID: 7576306 Published · ppublish English Journal Article Review

Retinoic acid and retinoic acid receptors in development.

Molecular neurobiology ·Vol. 10 ·No. 2-3 ·1995-00-00 ·Pages 169-84

Sucov HM, Evans RM

Abstract

The vitamin A derivative retinoic acid (RA) and related compounds (retinoids) are utilized as signaling molecules in a diverse array of developmental and physiological regulatory processes, including many important in the developing and mature nervous system. Retinoids function by interaction with high affinity receptors of the nuclear receptor family, which also mediate the effects of steroid and thyroid hormones and which act in the nucleus as transcription factors. This review summarizes current knowledge of the molecular mechanisms of retinoid action, the complex role of retinoid receptors in a variety of hormonal signaling processes, and illustrates current efforts to more fully understand the biological functions of retinoid receptors through analysis of downstream gene regulatory networks and studies of mouse gene knockout systems.

MeSH Terms
Animals Base Sequence Cell Differentiation Cells, Cultured Embryonic and Fetal Development Gene Expression Regulation, Developmental Genes Hormones/physiology Humans Mice Mice, Knockout Molecular Sequence Data Nervous System/embryology Nervous System Malformations Neurons/cytology,metabolism Receptors, Retinoic Acid/classification,genetics,physiology Signal Transduction Transcription Factors/physiology Transcription, Genetic Vitamin A/physiology
Chemicals
Hormones Receptors, Retinoic Acid Transcription Factors Vitamin A
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sucov H M
Department of Cell and Neurobiology, University of Southern California School of Medicine, Los Angeles, USA.
Evans R M
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Article Info
Journal
Molecular neurobiology
Abbr.
Mol Neurobiol
ISSN
0893-7648
DOI
10.1007/BF02740674
Published
1995-00-00
Pages
169-84
Language
English
Region
United States
NLM ID
8900963
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02740674 View journal details
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