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PMID: 7569 Published · ppublish English Journal Article

Membrane receptors for hormones and neurotransmitters.

The Journal of cell biology ·Vol. 70 ·No. 2 pt 1 ·1976-08-00 ·Pages 261-86

Kahn CR

Abstract

Receptors for peptide hormones and neurotransmitters are integral components of the plasma membrane of cells which serve to couple the external milieu to the intracellular regulators of metabolism. These macromolecules are usually high molecular weight glycoproteins, and in many cases appear to have more than one subunit capable of binding the hormone. The interaction of the hormone or neurotransmitter with its receptor is rapid, reversible, and of high affinity and specificity. Many receptors exhibit cooperative properties in hormone binding or biological function. The concentration of receptors on the membrane is a function of continued synthesis and degradation, and may be altered by a variety of factors including the hormone itself. The fluid mosaic nature of the membrane may allow hormone receptors and effectors to exist in free floating states. Further investigations of the hormone-receptor interaction will no doubt yield new insights into both the mechanism of hormone action and membrane structure and function.

MeSH Terms
Amino Acids/analysis Animals Binding Sites Binding, Competitive Cell Division Cell Fractionation Cell Membrane/metabolism,ultrastructure Cell Transformation, Neoplastic Hormones/metabolism Humans Insulin/metabolism Kinetics Mathematics Models, Biological Molecular Weight Neurotransmitter Agents/metabolism Organoids/analysis Protein Conformation Receptors, Adrenergic Receptors, Cell Surface Receptors, Cholinergic Structure-Activity Relationship
Chemicals
Amino Acids Hormones Insulin Neurotransmitter Agents Receptors, Adrenergic Receptors, Cell Surface Receptors, Cholinergic
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kahn C R
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121 references, click to expand
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.70.2.261
Published
1976-08-00
Pages
261-86
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2109819
Subset
IM
External Links
PubMed source DOI: 10.1083/jcb.70.2.261 PMC Full Text View journal details
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