Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance.

Science (New York, N.Y.) ·Vol. 190 ·No. 4209 ·1975-10-03 ·Pages 63-5

Flier JS, Kahn CR, Roth J, Bar RS

Abstract

Six patients with a unique form of diabetes associated with extreme insulin resistance have markedly reduced insulin binding to specific receptors on their circulating monocytes. When normal insulin receptors were exposed to serum or immunoglobulin fractions from three of these patients in vitro the specific binding defect was reproduced.

MeSH Terms

Animals Antigen-Antibody Reactions Autoantibodies Binding Sites Diabetes Mellitus/immunology,metabolism Erythrocytes/metabolism Female Humans Insulin/metabolism Insulin Resistance Liver/metabolism Lymphocytes/metabolism Monocytes/immunology,metabolism Rats Receptors, Cell Surface Syndrome

Chemicals

Autoantibodies Insulin Receptors, Cell Surface

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Flier J S

Kahn C R

Roth J

Bar R S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.170678

Published

1975-10-03

Pages

63-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.170678 View journal details

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Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance.

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