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PMID: 7524102 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Role of the 75-kDa tumor necrosis factor receptor: inhibition of early hematopoiesis.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 22 ·1994-10-25 ·Pages 10695-9

Jacobsen FW, Rothe M, Rusten L, Goeddel DV, Smeland EB, Veiby OP, Slørdal L, Jacobsen SE

Abstract

Biological effects of tumor necrosis factor alpha (TNF-alpha) are mediated through two cell surface receptors, the 55-kDa TNF receptor and the 75-kDa TNF receptor. The present study investigated the relative roles of the two TNF receptors in normal hematopoiesis. Using agonists (antibodies) specific for the 55- and 75-kDa TNF receptors, we demonstrate differential roles of the two TNF receptors in hematopoiesis in that only the 55-kDa TNF receptor mediates antiproliferative effects of TNF-alpha on mature Lin- hematopoietic progenitor cells responding to granulocyte colony-stimulating factor or interleukin 3 alone. In contrast, the 75-kDa TNF receptor is essential in mediating inhibition of primitive Lin-Sca-1+ high-proliferative-potential colony-forming cells and inhibition of the total number of proliferative clones of individually cultured Lin-Sca-1+Rh123lo and Lin-Sca-1+Rh123hi cells.

MeSH Terms
Animals Bone Marrow Cells Cell Differentiation/drug effects Cell Division/drug effects Cells, Cultured Colony-Forming Units Assay Granulocyte Colony-Stimulating Factor/pharmacology Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology Hematopoiesis/drug effects Hematopoietic Stem Cells/cytology,drug effects,physiology Humans Macrophage Colony-Stimulating Factor/pharmacology Mice Mice, Inbred C57BL Molecular Weight Radioligand Assay Receptors, Tumor Necrosis Factor/drug effects,physiology Recombinant Proteins/pharmacology Tumor Necrosis Factor-alpha/pharmacology
Chemicals
Receptors, Tumor Necrosis Factor Recombinant Proteins Tumor Necrosis Factor-alpha Granulocyte Colony-Stimulating Factor Macrophage Colony-Stimulating Factor Granulocyte-Macrophage Colony-Stimulating Factor
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Jacobsen F W
Department of Immunology, Norwegian Radium Hospital, Montebello, Oslo.
Rothe M
Rusten L
Goeddel D V
Smeland E B
Veiby O P
Slørdal L
Jacobsen S E
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.22.10695
Published
1994-10-25
Pages
10695-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC45088
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.91.22.10695 PMC Full Text View journal details
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