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PMID: 7513432 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Thalidomide is an inhibitor of angiogenesis.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 9 ·1994-04-26 ·Pages 4082-5

D'Amato RJ, Loughnan MS, Flynn E, Folkman J

Abstract

Thalidomide is a potent teratogen causing dysmelia (stunted limb growth) in humans. We have demonstrated that orally administered thalidomide is an inhibitor of angiogenesis induced by basic fibroblast growth factor in a rabbit cornea micropocket assay. Experiments including the analysis of thalidomide analogs revealed that the antiangiogenic activity correlated with the teratogenicity but not with the sedative or the mild immunosuppressive properties of thalidomide. Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of thalidomide-treated embryos. These experiments shed light on the mechanism of thalidomide's teratogenicity and hold promise for the potential use of thalidomide as an orally administered drug for the treatment of many diverse diseases dependent on angiogenesis.

MeSH Terms
Animals Chick Embryo Cornea Fibroblast Growth Factor 2/pharmacology In Vitro Techniques Neovascularization, Pathologic Rabbits Thalidomide/pharmacology
Chemicals
Fibroblast Growth Factor 2 Thalidomide
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
D'Amato R J
Department of Surgery, Children's Hospital, Harvard Medical School, Boston 02115.
Loughnan M S
Flynn E
Folkman J
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24 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.9.4082
Published
1994-04-26
Pages
4082-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC43727
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.91.9.4082 PMC Full Text View journal details
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