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PMID: 7474147 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Human T-lymphotropic virus type 1 in coastal natives of British Columbia: phylogenetic affinities and possible origins.

Journal of virology ·Vol. 69 ·No. 11 ·1995-11-00 ·Pages 7248-56

Picard FJ, Coulthart MB, Oger J, King EE, Kim S, Arp J, Rice GP, Dekaban GA

Abstract

Human T-lymphotropic virus type 1 (HTLV-1) infection has been discovered recently in people of Amerindian descent living in coastal areas of British Columbia, Canada. DNA sequencing combined with phylogenetic analysis and restriction fragment length polymorphism (RFLP) typing of HTLV-1 strains recovered from these British Columbia Indians (BCI) was conducted. Sequence-based phylogenetic trees distributed the BCI isolates among the Japanese subcluster (subcluster B) and the geographically widely distributed subcluster (subcluster A) of the large HTLV-1 cosmopolitan cluster. Long terminal repeat (LTR) RFLP typing revealed three distinct, equally frequent LTR cleavage patterns, two of which were of previously recognized Japanese and widely dispersed cosmopolitan types. A third, new cleavage pattern was detected which may have arisen by recombination between two other HTLV-1 genotypes. Our results suggest multiple origins for HTLV-1 in BCI, which are equally consistent with (i) a cluster of recent sporadic infections, (ii) ancient endemic vertical transmission through Amerindian lineages, or (iii) both.

MeSH Terms
Base Sequence British Columbia/epidemiology DNA Primers Demography HTLV-I Infections/epidemiology,virology Human T-lymphotropic virus 1/classification,genetics,isolation & purification Humans Indians, North American Molecular Sequence Data Phylogeny Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Repetitive Sequences, Nucleic Acid Species Specificity
Chemicals
DNA Primers
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Picard F J
Gene Therapy and Molecular Virology Group, John P. Robarts Research Institute, London, Ontario, Canada.
Coulthart M B
Oger J
King E E
Kim S
Arp J
Rice G P
Dekaban G A
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.69.11.7248-7256.1995
Published
1995-11-00
Pages
7248-56
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC189647
Subset
IM
Databases
GENBANK
U32552, U32553, U32554, U32555, U32556, U32557, U32558
External Links
PubMed source DOI: 10.1128/JVI.69.11.7248-7256.1995 PMC Full Text View journal details
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