Home LiteratureArticle Details
PMID: 1548762 Published · ppublish English Journal Article

Low degree of human T-cell leukemia/lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations.

Journal of virology ·Vol. 66 ·No. 4 ·1992-04-00 ·Pages 2288-95

Gessain A, Gallo RC, Franchini G

Abstract

We have studied the genetic variation of human T-cell leukemia/lymphoma virus type I (HTLV-I) isolates in the same individuals over time, as well as of HTLV-I isolates from various parts of the world. The viral DNA fragment studied encodes the carboxy terminus of gp46 and almost all of gp21, both of which are envelope glycoproteins. Samples were obtained from native inhabitants of five African countries, two South American countries, China, the French West Indies, and Haiti and included 14 patients with tropical spastic paraparesis/HTLV-I-associated myelopathy, 10 patients with adult T-cell leukemia, 1 patient with T-cell non-Hodgkin's lymphoma, and 3 healthy HTLV-I-seropositive individuals. DNA analyses of HTLV-I sequences demonstrated that (i) little or no genetic variation occurred in vivo in the same individual or in different hosts from the same region carrying the same virus, regardless of their clinical statuses; (ii) changes in nucleotide sequences in some regions of the HTLV-I genome were diagnostic of the geographical origin of the viruses; (iii) HTLV-I sequences from West African countries (Mauritania and Guinea Bissau) and some from the Ivory Coast and Central African Republic were virtually identical to those from the French West Indies, Haiti, French Guyana, and Peru, strongly suggesting that at least some HTLV-I strains were introduced into the New World through infected individuals during the slave trade events; and (iv) the Zairian HTLV-I isolates represent a separate HTLV-I cluster, in which intrastrain variability was also observed, and are more divergent from the other HTLV-I isolates. Because of the low genetic variability of HTLV-I in vivo, the study of the proviral DNA sequence in selected populations of infected individuals will increase our knowledge of the origin and evolution of HTLV-I and might be useful in anthropological studies.

MeSH Terms
Base Sequence Biological Evolution DNA, Viral Gene Frequency Genetic Variation HTLV-I Infections/microbiology,transmission Human T-lymphotropic virus 1/genetics,isolation & purification Humans Male Molecular Sequence Data Sequence Homology, Nucleic Acid
Chemicals
DNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Gessain A
Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Gallo R C
Franchini G
References (42)
42 references, click to expand
  1. Chronic myelopathies associated with human T-lymphotropic virus type I. A clinical, serologic, and immunovirologic study of ten patients in France.
    Arch Neurol. 1989 Mar;46(3):255-60 PMID: 2919977
  2. Nucleotide sequence analysis of a provirus derived from HTLV-1-associated myelopathy (HAM).
    Mol Biol Med. 1988 Feb;5(1):29-42 PMID: 2897612
  3. Adult T-cell lymphoma-leukaemia in Blacks from the West Indies.
    Lancet. 1982 Mar 20;1(8273):639-43 PMID: 6121963
  4. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.
    Proc Natl Acad Sci U S A. 1980 Dec;77(12):7415-9 PMID: 6261256
  5. Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.
    Proc Natl Acad Sci U S A. 1983 Jun;80(12):3618-22 PMID: 6304725
  6. The detection of human T cell leukemia virus proviral DNA and its application for classification and diagnosis of T cell malignancy.
    Blood. 1984 May;63(5):1235-40 PMID: 6324929
  7. Sequence variability of bovine leukemia virus env gene and its relevance to the structure and antigenicity of the glycoproteins.
    J Virol. 1990 Sep;64(9):4180-8 PMID: 1696635
  8. High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis.
    Blood. 1990 Jan 15;75(2):428-33 PMID: 1967218
  9. Sequence variations in LTR and env regions of HTLV-I do not discriminate between the virus from patients with HTLV-I-associated myelopathy and adult T-cell leukemia.
    Int J Cancer. 1991 Feb 20;47(4):491-5 PMID: 1995478
  10. Characterization of a variant of human T-lymphotropic virus type I isolated from a healthy member of a remote, recently contacted group in Papua New Guinea.
    Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1446-50 PMID: 1996344
  11. Mutations introduced along the HTLV-I envelope gene result in a non-functional protein: a basis for envelope conservation?
    EMBO J. 1990 Dec;9(13):4243-8 PMID: 2124968
  12. Epidemiology and immunovirology of human T-cell leukemia/lymphoma virus type I-associated adult T-cell leukemia and chronic myelopathies as seen in France.
    Cancer Res. 1990 Sep 1;50(17 Suppl):5692S-5696S PMID: 2201441
  13. Retrovirus from human T-cell leukemia virus type I-associated myelopathy is the same strain as a prototype human T-cell leukemia virus type I.
    Arch Neurol. 1990 Nov;47(11):1258-60 PMID: 2241626
  14. A cluster of HTLV-1 associated tropical spastic paraparesis in Equateur (Zaire): ethnic and familial distribution.
    J Neurol Neurosurg Psychiatry. 1990 Jan;53(1):4-10 PMID: 2303831
  15. Human T cell lymphotropic virus type I (HTLV-I) among female prostitutes in Kinshasa, Zaire.
    J Infect Dis. 1990 Jun;161(6):1073-7 PMID: 2345292
  16. Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS.
    Cell. 1986 Jun 6;45(5):637-48 PMID: 2423250
  17. Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients.
    Cell. 1986 Jul 4;46(1):63-74 PMID: 2424612
  18. Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations.
    Cell. 1989 Sep 8;58(5):901-10 PMID: 2550139
  19. Human retroviruses HTLV-I, HIV-1, and HIV-2 and neurological diseases in some equatorial areas of Africa.
    J Acquir Immune Defic Syndr. 1989;2(6):550-6 PMID: 2585247
  20. Seroepidemiological survey of HTLV-I infection among randomized populations of western central African countries.
    J Acquir Immune Defic Syndr. 1989;2(4):410-3 PMID: 2754613
  21. HTLV-I associated myelopathy, a new clinical entity.
    Lancet. 1986 May 3;1(8488):1031-2 PMID: 2871307
  22. Molecular cloning and complete nucleotide sequence of an adult T cell leukaemia virus/human T cell leukaemia virus type I (ATLV/HTLV-I) isolate of Caribbean origin: relationship to other members of the ATLV/HTLV-I subgroup.
    J Gen Virol. 1988 Jul;69 ( Pt 7):1695-710 PMID: 2899128
  23. Nucleotide sequence analysis of a variant human T-cell leukemia virus (HTLV-Ib) provirus with a deletion in pX-I.
    J Virol. 1985 Jun;54(3):781-90 PMID: 2987530
  24. Prevalence of a human retrovirus in native Japanese: evidence for a possible ancient origin.
    J Infect. 1985 Sep;11(2):153-7 PMID: 2997332
  25. Envelope sequences of two new United States HIV-1 isolates.
    Virology. 1988 Jun;164(2):531-6 PMID: 3369091
  26. Origin of human T-cell leukaemia-lymphoma virus.
    Lancet. 1983 Oct 22;2(8356):962-3 PMID: 6138516
  27. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS.
    Science. 1984 May 4;224(4648):497-500 PMID: 6200935
  28. The human type-C retrovirus, HTLV, in Blacks from the Caribbean region, and relationship to adult T-cell leukemia/lymphoma.
    Int J Cancer. 1982 Sep 15;30(3):257-64 PMID: 6290401
  29. The human T-cell leukemia-lymphoma virus in the southeastern United States.
    JAMA. 1983 Aug 26;250(8):1048-52 PMID: 6308290
  30. Natural antibodies to human retrovirus HTLV in a cluster of Japanese patients with adult T cell leukemia.
    Science. 1982 Feb 19;215(4535):975-8 PMID: 6760397
  31. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
  32. Highly divergent molecular variants of human T-lymphotropic virus type I from isolated populations in Papua New Guinea and the Solomon Islands.
    Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7694-8 PMID: 1881912
  33. Non-spastic paraparesis associated with HTLV-I.
    Lancet. 1990 Jul 28;336(8709):260 PMID: 1973818
  34. In vivo genomic variability of human T-cell leukemia virus type I depends more upon geography than upon pathologies.
    J Virol. 1991 Jul;65(7):3770-8 PMID: 2041093
  35. Nucleotide sequence analysis of a provirus derived from an individual with tropical spastic paraparesis.
    Microb Pathog. 1990 Apr;8(4):259-78 PMID: 2200942
  36. Rapid development of myelopathy after HTLV-I infection acquired by transfusion during cardiac transplantation.
    N Engl J Med. 1990 Feb 8;322(6):383-8 PMID: 2300089
  37. Sequence variants of human T-cell lymphotropic virus type I from patients with tropical spastic paraparesis and adult T-cell leukemia do not distinguish neurological from leukemic isolates.
    J Virol. 1990 Mar;64(3):1278-82 PMID: 2304144
  38. Envelope gene sequence of HTLV-1 isolate MT-2 and its comparison with other HTLV-1 isolates.
    Virology. 1990 Jul;177(1):391-5 PMID: 2353464
  39. The first human retrovirus.
    Sci Am. 1986 Dec;255(6):88-98 PMID: 2434991
  40. Seroprevalence of HTLV-I in Portugal and evidence of double retrovirus infection of a healthy donor.
    Int J Cancer. 1989 Feb 15;43(2):195-200 PMID: 2563718
  41. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis.
    Lancet. 1985 Aug 24;2(8452):407-10 PMID: 2863442
  42. Rapid evolution of RNA viruses.
    Annu Rev Microbiol. 1987;41:409-33 PMID: 3318675
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.66.4.2288-2295.1992
Published
1992-04-00
Pages
2288-95
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC289023
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.66.4.2288-2295.1992 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2